Duration Of Infection-Derived Immunity To Cholera

M. M. Levine, R. E. Black, M. L. Clements, L. Cisneros, D. R. Nalin, C. R. Young

Research output: Contribution to journalArticlepeer-review

167 Scopus citations


Four volunteers were rechallenged with Vibrio cholerae (106 classical Ogawa 395 organisms) 33-36 months after their initial induced cholera infection; none of the four veterans and four of five control volunteers developed diarrhea (P = 0.04). All control subjects, but only one veteran, had positive coprocultures. Three of the four veterans had significant levels of serum IgG antitoxin before challenge, but none had measurable intestinal levels of secretory IgA antitoxin. Significant rises in levels of serum vibriocidal and antitoxic antibody occurred in all control subjects and in two veterans, who also manifested rises in levels of intestinal secretory IgA antitoxin. The impressive duration of infection-derived immunity suggests that the most promising approach to development of cholera vaccines may be to mimic natural immunity with orally administered, attenuated strains of V. cholerae.

Original languageEnglish (US)
Pages (from-to)818-820
Number of pages3
JournalJournal of Infectious Diseases
Issue number6
StatePublished - Apr 1981
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases


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