Durable HIV RNA resuppression after virologic failure while remaining on a first-line regimen: A cohort study

Christopher J. Hoffmann; Salome Charalambous; Alison D. Grant; Lynn Morris; Gavin J. Churchyard; Richard E. Chaisson

doi:10.1111/tmi.12237

Durable HIV RNA resuppression after virologic failure while remaining on a first-line regimen: A cohort study

Christopher J. Hoffmann, Salome Charalambous, Alison D. Grant, Lynn Morris, Gavin J. Churchyard, Richard E. Chaisson

School of Medicine

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Summary: Adherence interventions are a recommended strategy to salvage failing antiretroviral therapy without regimen change. We assessed the durability of resuppression when using this approach. Of 300 patients who resuppressed on the same regimen (41% of all those with virologic failure), 148 (45%) remained suppressed during follow-up for a median of 2.4 years (interquartile range [IQR]: 1.1, 4.0). Resuppression can be durable following viraemia without a switch in antiretroviral therapy regimen.

Original language	English (US)
Pages (from-to)	236-239
Number of pages	4
Journal	Tropical Medicine and International Health
Volume	19
Issue number	2
DOIs	https://doi.org/10.1111/tmi.12237
State	Published - Feb 2014

Keywords

Adherence
Africa
Antiretroviral therapy
Clinical management
HIV
Treatment failure

ASJC Scopus subject areas

Parasitology
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1111/tmi.12237

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title = "Durable HIV RNA resuppression after virologic failure while remaining on a first-line regimen: A cohort study",

abstract = "Summary: Adherence interventions are a recommended strategy to salvage failing antiretroviral therapy without regimen change. We assessed the durability of resuppression when using this approach. Of 300 patients who resuppressed on the same regimen (41% of all those with virologic failure), 148 (45%) remained suppressed during follow-up for a median of 2.4 years (interquartile range [IQR]: 1.1, 4.0). Resuppression can be durable following viraemia without a switch in antiretroviral therapy regimen.",

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T1 - Durable HIV RNA resuppression after virologic failure while remaining on a first-line regimen

T2 - A cohort study

AU - Hoffmann, Christopher J.

AU - Charalambous, Salome

AU - Grant, Alison D.

AU - Morris, Lynn

AU - Churchyard, Gavin J.

AU - Chaisson, Richard E.

PY - 2014/2

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AB - Summary: Adherence interventions are a recommended strategy to salvage failing antiretroviral therapy without regimen change. We assessed the durability of resuppression when using this approach. Of 300 patients who resuppressed on the same regimen (41% of all those with virologic failure), 148 (45%) remained suppressed during follow-up for a median of 2.4 years (interquartile range [IQR]: 1.1, 4.0). Resuppression can be durable following viraemia without a switch in antiretroviral therapy regimen.

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KW - Antiretroviral therapy

KW - Clinical management

KW - HIV

KW - Treatment failure

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Durable HIV RNA resuppression after virologic failure while remaining on a first-line regimen: A cohort study

Abstract

Keywords

ASJC Scopus subject areas

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