Durability of Spike Immunoglobin G Antibodies to SARS-CoV-2 Among Health Care Workers With Prior Infection

Emily R. Egbert; Shaoming Xiao; Elizabeth Colantuoni; Patrizio Caturegli; Avinash Gadala; Aaron M. Milstone; Amanda K. Debes

doi:10.1001/jamanetworkopen.2021.23256

Durability of Spike Immunoglobin G Antibodies to SARS-CoV-2 Among Health Care Workers With Prior Infection

Emily R. Egbert
, Shaoming Xiao
, Elizabeth Colantuoni
, Patrizio Caturegli
, Avinash Gadala
, Aaron M. Milstone
, Amanda K. Debes

Research output: Contribution to journal › Article › peer-review

Abstract

Herd immunity is needed to reduce deaths, prevent transmission, and minimize the emergence of SARS-CoV-2 variants. The durability of serum antibodies against the spike protein of this virus provides insights into immunologic memory following natural infection.¹ Recent literature supports that the levels of spike antibodies induced by natural infection correlate with neutralization and protect against subsequent infection.² We evaluated the durability of naturally acquired spike immunoglobin (Ig) G antibodies to SARS-CoV-2 among a cohort of health care workers.

Original language	English (US)
Pages (from-to)	E2123256
Journal	JAMA Network Open
Volume	4
Issue number	8
DOIs	https://doi.org/10.1001/jamanetworkopen.2021.23256
State	Published - Aug 30 2021

ASJC Scopus subject areas

General Medicine

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abstract = "Herd immunity is needed to reduce deaths, prevent transmission, and minimize the emergence of SARS-CoV-2 variants. The durability of serum antibodies against the spike protein of this virus provides insights into immunologic memory following natural infection.1 Recent literature supports that the levels of spike antibodies induced by natural infection correlate with neutralization and protect against subsequent infection.2 We evaluated the durability of naturally acquired spike immunoglobin (Ig) G antibodies to SARS-CoV-2 among a cohort of health care workers.",

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AU - Egbert, Emily R.

AU - Xiao, Shaoming

AU - Colantuoni, Elizabeth

AU - Caturegli, Patrizio

AU - Gadala, Avinash

AU - Milstone, Aaron M.

AU - Debes, Amanda K.

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AB - Herd immunity is needed to reduce deaths, prevent transmission, and minimize the emergence of SARS-CoV-2 variants. The durability of serum antibodies against the spike protein of this virus provides insights into immunologic memory following natural infection.1 Recent literature supports that the levels of spike antibodies induced by natural infection correlate with neutralization and protect against subsequent infection.2 We evaluated the durability of naturally acquired spike immunoglobin (Ig) G antibodies to SARS-CoV-2 among a cohort of health care workers.

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JO - JAMA Network Open

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Durability of Spike Immunoglobin G Antibodies to SARS-CoV-2 Among Health Care Workers With Prior Infection

Abstract

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