Abstract
A dual-band water and lipid suppression sequence was developed for multislice sensitivity-encoded proton MR spectroscopic imaging of the human brain. The presaturation scheme consisted of five dual-band frequency-modulated radiofrequency pulses based on hypergeometric functions integrated with eight outer volume suppression (OVS) pulses. The flip angles of the dual-band pulses were optimized through computer simulations to maximize suppression factors over a range of transmitter amplitude of radiofrequency field and water and lipid T1 values. The resulting hypergeometric dual band with OVS (HGDB + OVS) sequence was implemented at 3 T in a multislice sensitivity-encoded proton MR spectroscopic imaging experiment and compared to a conventional water suppression scheme (variable pulse power and optimized relaxation delays (VAPOR)) with OVS. The HGDB sequence was significantly shorter than the VAPOR sequence (230 versus 728 msec). Both HGDB + OVS and VAPOR + OVS produced good water suppression, while lipid suppression with the HGDB + OVS sequence was far superior. In sensitivity-encoded proton MR spectroscopic imaging data, artifacts from extracranial lipid signals were significantly lower with HGDB + OVS. The shorter duration of HGDB compared to VAPOR also allows reduced pulse repetition time values in the multislice acquisition.
Original language | English (US) |
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Pages (from-to) | 1486-1492 |
Number of pages | 7 |
Journal | Magnetic resonance in medicine |
Volume | 63 |
Issue number | 6 |
DOIs | |
State | Published - Jun 2010 |
Keywords
- Brain
- Lipid suppression
- Magnetic resonance spectroscopic imaging
- Sensitivity-encoding
- Water suppression
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging