Drug-induced hepatotoxicity: Metabolic, genetic and immunological basis

Dolores B. Njoku

doi:10.3390/ijms15046990

Drug-induced hepatotoxicity: Metabolic, genetic and immunological basis

Dolores B. Njoku

Research output: Contribution to journal › Review article › peer-review

40 Scopus citations

Abstract

Drug-induced hepatotoxicity is a significant cause of acute liver failure and is usually the primary reason that therapeutic drugs are removed from the commercial market. Multiple mechanisms can culminate in drug hepatotoxicity. Metabolism, genetics and immunology separately and in concert play distinct and overlapping roles in this process. This review will cover papers we feel have addressed these mechanisms of drug-induced hepatotoxicity in adults following the consumption of commonly used medications. The aim is to generate discussion around "trigger point" papers where the investigators generated new science or provided additional contribution to existing science. Hopefully these discussions will assist in uncovering key areas that need further attention.

Original language	English (US)
Pages (from-to)	6990-7003
Number of pages	14
Journal	International journal of molecular sciences
Volume	15
Issue number	4
DOIs	https://doi.org/10.3390/ijms15046990
State	Published - Apr 22 2014
Externally published	Yes

Keywords

Drug induced liver injury (DILI)
Hepatotoxicity
Pathogenesis

ASJC Scopus subject areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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10.3390/ijms15046990

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AB - Drug-induced hepatotoxicity is a significant cause of acute liver failure and is usually the primary reason that therapeutic drugs are removed from the commercial market. Multiple mechanisms can culminate in drug hepatotoxicity. Metabolism, genetics and immunology separately and in concert play distinct and overlapping roles in this process. This review will cover papers we feel have addressed these mechanisms of drug-induced hepatotoxicity in adults following the consumption of commonly used medications. The aim is to generate discussion around "trigger point" papers where the investigators generated new science or provided additional contribution to existing science. Hopefully these discussions will assist in uncovering key areas that need further attention.

KW - Drug induced liver injury (DILI)

KW - Hepatotoxicity

KW - Pathogenesis

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JO - International journal of molecular sciences

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Drug-induced hepatotoxicity: Metabolic, genetic and immunological basis

Abstract

Keywords

ASJC Scopus subject areas

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