Drug-induced hepatotoxicity: Metabolic, genetic and immunological basis

Dolores B. Njoku

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations


Drug-induced hepatotoxicity is a significant cause of acute liver failure and is usually the primary reason that therapeutic drugs are removed from the commercial market. Multiple mechanisms can culminate in drug hepatotoxicity. Metabolism, genetics and immunology separately and in concert play distinct and overlapping roles in this process. This review will cover papers we feel have addressed these mechanisms of drug-induced hepatotoxicity in adults following the consumption of commonly used medications. The aim is to generate discussion around "trigger point" papers where the investigators generated new science or provided additional contribution to existing science. Hopefully these discussions will assist in uncovering key areas that need further attention.

Original languageEnglish (US)
Pages (from-to)6990-7003
Number of pages14
JournalInternational journal of molecular sciences
Issue number4
StatePublished - Apr 22 2014


  • Drug induced liver injury (DILI)
  • Hepatotoxicity
  • Pathogenesis

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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