Abstract
Gynecomastia is caused by drugs in 10-25% of all cases. The pathophysiologic mechanism for some drugs includes exogenous estrogens exposure, medications that cause hypogonadism, anti-androgenic effects and hyperprolactinemia. This manuscript reviews common examples of drug-induced gynecomastia, discussing the mechanisms and possible treatments. Discontinuing the medication is always the best choice; however, if this is not possible, then testosterone replacement therapy may be needed for hypogonadism. When a man is euogonadal, a trial of the anti-estrogen, tamoxifen or an aromatase inhibitor may be an option.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 691-702 |
| Number of pages | 12 |
| Journal | Expert Opinion on Drug Safety |
| Volume | 7 |
| Issue number | 6 |
| DOIs | |
| State | Published - Nov 2008 |
Keywords
- Breast
- Drug-induced
- Gynecomastia
- Hypogonadism
ASJC Scopus subject areas
- Pharmacology (medical)