Drug Efficacy Testing in the Mouse Footpad Model of Buruli Ulcer

Paul J. Converse, Deepak V. Almeida, Eric L. Nuermberger

Research output: Chapter in Book/Report/Conference proceedingChapter


Great progress has been made in understanding the pathogenesis and treatment of Buruli ulcer over the last 20 years. The rediscovery of the mouse footpad model of the disease with translation to clinical practice has changed treatment of this infectious disease, caused by Mycobacterium ulcerans, from surgery and skin grafting to the administration of antibiotics for 8 weeks or less with superior cure rates. Here we describe the development and enhancement of the mouse model during the last two decades.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Number of pages13
StatePublished - 2022

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029


  • Buruli ulcer
  • Mycobacterium ulcerans

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology


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