Drug discovery using human ipsc based disease models and functional hepatic cells

Su Mi Choi, Yonghak Kim, Yoon Young Jang

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The development of human induced pluripotent stem cell (iPSC) technology has generated enthusiasm about the therapeutic potential of these cells for treating a variety of diseases. During the past few years, iPSC generation and hepatic differentiation methods have been significantly improved. These will provide an unlimited source of functional hepatocytes not only for transplantation, but for efficient drug discovery via patient relevantmodeling of liver diseases and of drug-induced hepatotoxicity. Here we discuss the near future applications (and challenges) of iPSC-based cellular models, with an emphasis on liver diseases, cancer and hepatocytes.

Original languageEnglish (US)
Title of host publicationStem Cells and Cancer Stem Cells, Volume 10
Subtitle of host publicationTherapeutic Applications in Disease and Injury
PublisherSpringer Netherlands
Pages95-103
Number of pages9
ISBN (Electronic)9789400762626
ISBN (Print)9789400762619
DOIs
StatePublished - Jan 1 2013

ASJC Scopus subject areas

  • General Medicine

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