Drug and psychotherapy interactions in depression

L. Covi, R. S. Lipman, R. D. Alarcon, V. K. Smith

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


The authors conducted a series of multiple regression analyses of data from depressed patients. They found that 8 factors consistently predicted treatment response: a lower initial level of distress, imipramine treatment, a positive attitude toward group psychotherapy, and a good employment history predicted lower posttreatment distress levels; estrogen maintenance treatment was related to better response to diazepam, and a low level of intelligence predicted better response to both diazepam and imipramine; and a low initial level of interpersonal sensitivity and a significant other's having an unfavorable attitude toward psychiatric treatment were associated with better response to group psychotherapy.

Original languageEnglish (US)
Pages (from-to)502-508
Number of pages7
JournalAmerican Journal of Psychiatry
Issue number5
StatePublished - Jan 1 1976

ASJC Scopus subject areas

  • Psychiatry and Mental health


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