Driving the wedge: Understanding an improved Cas9 to better engineer others

Charles J. Lenihan; Scott Bailey

doi:10.1016/j.molcel.2024.05.026

Driving the wedge: Understanding an improved Cas9 to better engineer others

Charles J. Lenihan, Scott Bailey

Bloomberg School of Public Health

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

In their recent structural work, Eggers et al.¹ rationalize how key mutations in the WED domain of the compact and thermostable Geobacillus stearothermophilus Cas9 bolster its editing efficiency in mammalian cells, and they use these insights to rationally improve another Cas9.

Original language	English (US)
Pages (from-to)	2221-2222
Number of pages	2
Journal	Molecular cell
Volume	84
Issue number	12
DOIs	https://doi.org/10.1016/j.molcel.2024.05.026
State	Published - Jun 20 2024

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1016/j.molcel.2024.05.026

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title = "Driving the wedge: Understanding an improved Cas9 to better engineer others",

abstract = "In their recent structural work, Eggers et al.1 rationalize how key mutations in the WED domain of the compact and thermostable Geobacillus stearothermophilus Cas9 bolster its editing efficiency in mammalian cells, and they use these insights to rationally improve another Cas9.",

author = "Lenihan, {Charles J.} and Scott Bailey",

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year = "2024",

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language = "English (US)",

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T2 - Understanding an improved Cas9 to better engineer others

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AU - Bailey, Scott

PY - 2024/6/20

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AB - In their recent structural work, Eggers et al.1 rationalize how key mutations in the WED domain of the compact and thermostable Geobacillus stearothermophilus Cas9 bolster its editing efficiency in mammalian cells, and they use these insights to rationally improve another Cas9.

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UR - http://www.scopus.com/inward/citedby.url?scp=85196189142&partnerID=8YFLogxK

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DO - 10.1016/j.molcel.2024.05.026

M3 - Comment/debate

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AN - SCOPUS:85196189142

SN - 1097-2765

VL - 84

SP - 2221

EP - 2222

JO - Molecular cell

JF - Molecular cell

IS - 12

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Driving the wedge: Understanding an improved Cas9 to better engineer others

Abstract

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