DPEP1 inhibits tumor cell invasiveness, enhances chemosensitivity and predicts clinical outcome in pancreatic ductal adenocarcinoma

Geng Zhang; Aaron Schetter; Peijun He; Naotake Funamizu; Jochen Gaedcke; B. Michael Ghadimi; Thomas Ried; Raffit Hassan; Harris G. Yfantis; Dong H. Lee; Curtis Lacy; Anirban Maitra; Nader Hanna; H. Richard Alexander; S. Perwez Hussain

doi:10.1371/journal.pone.0031507

DPEP1 inhibits tumor cell invasiveness, enhances chemosensitivity and predicts clinical outcome in pancreatic ductal adenocarcinoma

Geng Zhang, Aaron Schetter, Peijun He, Naotake Funamizu, Jochen Gaedcke, B. Michael Ghadimi, Thomas Ried, Raffit Hassan, Harris G. Yfantis, Dong H. Lee, Curtis Lacy, Anirban Maitra, Nader Hanna, H. Richard Alexander, S. Perwez Hussain

School of Medicine

Research output: Contribution to journal › Article › peer-review

122 Scopus citations

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers worldwide. To identify biologically relevant genes with prognostic and therapeutic significance in PDAC, we first performed the microarray gene-expression profiling in 45 matching pairs of tumor and adjacent non-tumor tissues from resected PDAC cases. We identified 36 genes that were associated with patient outcome and also differentially expressed in tumors as compared with adjacent non-tumor tissues in microarray analysis. Further evaluation in an independent validation cohort (N = 27) confirmed that DPEP1 (dipeptidase 1) expression was decreased (T: N ratio ~0.1, P

Original language	English (US)
Article number	e31507
Journal	PLoS One
Volume	7
Issue number	2
DOIs	https://doi.org/10.1371/journal.pone.0031507
State	Published - Feb 20 2012

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

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Zhang, G., Schetter, A., He, P., Funamizu, N., Gaedcke, J., Ghadimi, B. M., Ried, T., Hassan, R., Yfantis, H. G., Lee, D. H., Lacy, C., Maitra, A., Hanna, N., Alexander, H. R., & Hussain, S. P. (2012). DPEP1 inhibits tumor cell invasiveness, enhances chemosensitivity and predicts clinical outcome in pancreatic ductal adenocarcinoma. PLoS One, 7(2), [e31507]. https://doi.org/10.1371/journal.pone.0031507

Zhang, G, Schetter, A, He, P, Funamizu, N, Gaedcke, J, Ghadimi, BM, Ried, T, Hassan, R, Yfantis, HG, Lee, DH, Lacy, C, Maitra, A, Hanna, N, Alexander, HR & Hussain, SP 2012, 'DPEP1 inhibits tumor cell invasiveness, enhances chemosensitivity and predicts clinical outcome in pancreatic ductal adenocarcinoma', PLoS One, vol. 7, no. 2, e31507. https://doi.org/10.1371/journal.pone.0031507

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AU - Zhang, Geng

AU - Schetter, Aaron

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AU - Gaedcke, Jochen

AU - Ghadimi, B. Michael

AU - Ried, Thomas

AU - Hassan, Raffit

AU - Yfantis, Harris G.

AU - Lee, Dong H.

AU - Lacy, Curtis

AU - Maitra, Anirban

AU - Hanna, Nader

AU - Alexander, H. Richard

AU - Hussain, S. Perwez

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DPEP1 inhibits tumor cell invasiveness, enhances chemosensitivity and predicts clinical outcome in pancreatic ductal adenocarcinoma

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