Doxorubicin (adriamycin): A critical review of free radical-dependent mechanisms of cytotoxicity

H. G. Keizer, H. M. Pinedo, G. J. Schuurhuis, H. Joenje

Research output: Contribution to journalArticlepeer-review

411 Scopus citations


The antineoplastic drug doxorubicin is capable of generating a variety of free radical species in subcellular systems and this capacity has been considered critical for its antitumor action. However, for most tumor cell lines this mechanism of cytotoxicity does not appear to play a major role. Free radical-independent cytotoxicity mechanisms, taking place in the nuclear compartment of the cell, may more likely be involved in the antitumor effect of doxorubicin.

Original languageEnglish (US)
Pages (from-to)219-231
Number of pages13
JournalPharmacology and Therapeutics
Issue number2
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology


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