Abstract
A 35-year-old man with aplastic anemia developed prominent downbeat nystagmus 80 days after receiving an allogeneic bone marrow transplant. A diagnosis of herpes simplex encephalitis was made which was confirmed by positive virus cultures at autopsy 1 week later. Routine pathologic examination of the brain stem revealed no lesions which would explain the downbeat nystagmus. Immunoperoxidase studies, however, revealed virus-infected neurones throughout the brain stem including the nuclei of the basis pontis, the superior olive, and nuclei of the spinal tracts of 5 and 10. The significance of “negative” pathologic brain stem findings in cases of downbeat nystagmus is discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 245-249 |
| Number of pages | 5 |
| Journal | Journal of Clinical Neuro-Ophthalmology |
| Volume | 3 |
| Issue number | 4 |
| State | Published - Dec 1983 |
ASJC Scopus subject areas
- Ophthalmology
- Clinical Neurology