Dose response biology: The case of resveratrol

Edward J. Calabrese, Mark P. Mattson, Vittorio Calabrese

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Resveratrol often displays hormesis-like biphasic dose responses. This occurs in a broad range of biological models and for numerous endpoints of biomedical interest and public health concern. Recognition of the widespread occurrence of the hormetic nature of many of the responses of resveratrol is important on multiple levels. It can help optimize study design protocols by investigators, create a dose-response framework for better addressing dose-related biological complexities and assist in the development of public health and medical guidance with respect to considerations for what is an optimal dose not just for an agent such as resveratrol, but also for the plethora of agents that also act via hormetic mechanisms.

Original languageEnglish (US)
Pages (from-to)1034-1037
Number of pages4
JournalHuman and Experimental Toxicology
Issue number12
StatePublished - Dec 2010
Externally publishedYes


  • adaptive response
  • biphasic
  • dose response
  • hormesis
  • hormetic
  • resveratrol
  • U-shaped

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis


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