TY - JOUR
T1 - Dose-Related Immunogenicity of Haemophilus influenzae Type b Capsular Polysaccharide—Neisseria meningitidis Outer Membrane Protein Conjugate Vaccine
AU - Wong, Victor K.
AU - Quagliata, Rory
AU - Adler, Robert
AU - Sik-Kim, Kwang
PY - 1991/7
Y1 - 1991/7
N2 - • We studied the immunologic responsiveness to Haemophilus influenzae type b capsular polysaccharide—Neisseria meningitidis group b outer membrane protein conjugate vaccine (PRP-NOMP) in children 2 to 42 months of age with vaccine dosages containing 7.5, 15, or 30 μg of PRP. Overall, PRP-NOMP was highly immunogenic. Geometric mean titers of anti-PRP antibody increased from 0.09 to 3.3 mg/L and 6.6 mg/L following each dose of vaccine, respectively, in the 2- to 18-month age group. Similarly, anti-PRP antibody geometric mean titers increased from 0.12 to 5.9 mg/L in the older than 18-month age group. However, we noted an apparent inverse relationship between vaccine dosages and immune responses following two doses of PRP-NOMP in 2- to 18-month-old children. Anti-PRP antibody geometric mean titers were 12.0,6.9, and 3.5 mg/L, respectively, after the second dose of vaccine containing 7.5,15, or 30 μg of PRP. Additional studies are needed to understand the mechanisms responsible for this inverse relationship and also to determine the optimal dosage of PRP-NOMP for young children. (AJDC. 1991;145:742-745)
AB - • We studied the immunologic responsiveness to Haemophilus influenzae type b capsular polysaccharide—Neisseria meningitidis group b outer membrane protein conjugate vaccine (PRP-NOMP) in children 2 to 42 months of age with vaccine dosages containing 7.5, 15, or 30 μg of PRP. Overall, PRP-NOMP was highly immunogenic. Geometric mean titers of anti-PRP antibody increased from 0.09 to 3.3 mg/L and 6.6 mg/L following each dose of vaccine, respectively, in the 2- to 18-month age group. Similarly, anti-PRP antibody geometric mean titers increased from 0.12 to 5.9 mg/L in the older than 18-month age group. However, we noted an apparent inverse relationship between vaccine dosages and immune responses following two doses of PRP-NOMP in 2- to 18-month-old children. Anti-PRP antibody geometric mean titers were 12.0,6.9, and 3.5 mg/L, respectively, after the second dose of vaccine containing 7.5,15, or 30 μg of PRP. Additional studies are needed to understand the mechanisms responsible for this inverse relationship and also to determine the optimal dosage of PRP-NOMP for young children. (AJDC. 1991;145:742-745)
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U2 - 10.1001/archpedi.1991.02160070038018
DO - 10.1001/archpedi.1991.02160070038018
M3 - Article
C2 - 2058604
AN - SCOPUS:84942185566
SN - 0002-922X
VL - 145
SP - 734
EP - 741
JO - American Journal of Diseases of Children
JF - American Journal of Diseases of Children
IS - 7
ER -