Dose enhancement during concomitant chemoradiotherapy using FDA approved concentrations of carboplatin and oxaliplatin nanoparticles

Gizem Cifter; Yucel Altundal; Alex Detappe; Erno Sajo; Ross Berbeco; Mike Makrigiorgos; Wilfred Ngwa

doi:10.1007/978-3-319-19387-8_418

Dose enhancement during concomitant chemoradiotherapy using FDA approved concentrations of carboplatin and oxaliplatin nanoparticles

Gizem Cifter, Yucel Altundal, Alex Detappe, Erno Sajo, Ross Berbeco, Mike Makrigiorgos, Wilfred Ngwa

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Radiation boosting has been shown in a number of studies to be effective in the prevention of cancer recurrence. To further the effectiveness of this technique, we propose a new method of enhancing dose locally by administrating nanoparticles of carboplatin (CaNPs) and oxaliplatin (ONPs) as adjuvants to brachytherapy and external beam therapy (EBRT). To investigate the efficacy of this method, dose enhancement calculations were carried out to calculate the energy deposited by photoelectrons and Auger electrons produced by low energy photons from either EBRT or brachytherapy sources with CaNPs and ONPs. Our results show a significant increase in the dose enhancement for various carboplatin and oxaliplatin concentrations up to their allowed FDA limits.

Original language	English (US)
Title of host publication	World Congress on Medical Physics and Biomedical Engineering, 2015
Editors	David A. Jaffray
Publisher	Springer Verlag
Pages	1723-1726
Number of pages	4
ISBN (Print)	9783319193878
DOIs	https://doi.org/10.1007/978-3-319-19387-8_418
State	Published - 2015
Externally published	Yes
Event	World Congress on Medical Physics and Biomedical Engineering, 2015 - Toronto, Canada Duration: Jun 7 2015 → Jun 12 2015

Publication series

Name	IFMBE Proceedings
Volume	51
ISSN (Print)	1680-0737

Other

Other	World Congress on Medical Physics and Biomedical Engineering, 2015
Country/Territory	Canada
City	Toronto
Period	6/7/15 → 6/12/15

Keywords

Carboplatin
Concomitant chemoradiotherapy
Dose enhancement
Nano particles
Oxaliplatin

ASJC Scopus subject areas

Bioengineering
Biomedical Engineering

Access to Document

10.1007/978-3-319-19387-8_418

Cite this

Cifter, G., Altundal, Y., Detappe, A., Sajo, E., Berbeco, R., Makrigiorgos, M., & Ngwa, W. (2015). Dose enhancement during concomitant chemoradiotherapy using FDA approved concentrations of carboplatin and oxaliplatin nanoparticles. In D. A. Jaffray (Ed.), World Congress on Medical Physics and Biomedical Engineering, 2015 (pp. 1723-1726). (IFMBE Proceedings; Vol. 51). Springer Verlag. https://doi.org/10.1007/978-3-319-19387-8_418

Dose enhancement during concomitant chemoradiotherapy using FDA approved concentrations of carboplatin and oxaliplatin nanoparticles. / Cifter, Gizem; Altundal, Yucel; Detappe, Alex et al.
World Congress on Medical Physics and Biomedical Engineering, 2015. ed. / David A. Jaffray. Springer Verlag, 2015. p. 1723-1726 (IFMBE Proceedings; Vol. 51).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Cifter, G, Altundal, Y, Detappe, A, Sajo, E, Berbeco, R, Makrigiorgos, M & Ngwa, W 2015, Dose enhancement during concomitant chemoradiotherapy using FDA approved concentrations of carboplatin and oxaliplatin nanoparticles. in DA Jaffray (ed.), World Congress on Medical Physics and Biomedical Engineering, 2015. IFMBE Proceedings, vol. 51, Springer Verlag, pp. 1723-1726, World Congress on Medical Physics and Biomedical Engineering, 2015, Toronto, Canada, 6/7/15. https://doi.org/10.1007/978-3-319-19387-8_418

Cifter G, Altundal Y, Detappe A, Sajo E, Berbeco R, Makrigiorgos M et al. Dose enhancement during concomitant chemoradiotherapy using FDA approved concentrations of carboplatin and oxaliplatin nanoparticles. In Jaffray DA, editor, World Congress on Medical Physics and Biomedical Engineering, 2015. Springer Verlag. 2015. p. 1723-1726. (IFMBE Proceedings). doi: 10.1007/978-3-319-19387-8_418

@inproceedings{c6def99db18e4138ae06070f90c0d36f,

title = "Dose enhancement during concomitant chemoradiotherapy using FDA approved concentrations of carboplatin and oxaliplatin nanoparticles",

abstract = "Radiation boosting has been shown in a number of studies to be effective in the prevention of cancer recurrence. To further the effectiveness of this technique, we propose a new method of enhancing dose locally by administrating nanoparticles of carboplatin (CaNPs) and oxaliplatin (ONPs) as adjuvants to brachytherapy and external beam therapy (EBRT). To investigate the efficacy of this method, dose enhancement calculations were carried out to calculate the energy deposited by photoelectrons and Auger electrons produced by low energy photons from either EBRT or brachytherapy sources with CaNPs and ONPs. Our results show a significant increase in the dose enhancement for various carboplatin and oxaliplatin concentrations up to their allowed FDA limits.",

keywords = "Carboplatin, Concomitant chemoradiotherapy, Dose enhancement, Nano particles, Oxaliplatin",

author = "Gizem Cifter and Yucel Altundal and Alex Detappe and Erno Sajo and Ross Berbeco and Mike Makrigiorgos and Wilfred Ngwa",

note = "Publisher Copyright: {\textcopyright} Springer International Publishing Switzerland 2015.; World Congress on Medical Physics and Biomedical Engineering, 2015 ; Conference date: 07-06-2015 Through 12-06-2015",

year = "2015",

doi = "10.1007/978-3-319-19387-8_418",

language = "English (US)",

isbn = "9783319193878",

series = "IFMBE Proceedings",

publisher = "Springer Verlag",

pages = "1723--1726",

editor = "Jaffray, {David A.}",

booktitle = "World Congress on Medical Physics and Biomedical Engineering, 2015",

}

TY - GEN

T1 - Dose enhancement during concomitant chemoradiotherapy using FDA approved concentrations of carboplatin and oxaliplatin nanoparticles

AU - Cifter, Gizem

AU - Altundal, Yucel

AU - Detappe, Alex

AU - Sajo, Erno

AU - Berbeco, Ross

AU - Makrigiorgos, Mike

AU - Ngwa, Wilfred

N1 - Publisher Copyright: © Springer International Publishing Switzerland 2015.

PY - 2015

Y1 - 2015

N2 - Radiation boosting has been shown in a number of studies to be effective in the prevention of cancer recurrence. To further the effectiveness of this technique, we propose a new method of enhancing dose locally by administrating nanoparticles of carboplatin (CaNPs) and oxaliplatin (ONPs) as adjuvants to brachytherapy and external beam therapy (EBRT). To investigate the efficacy of this method, dose enhancement calculations were carried out to calculate the energy deposited by photoelectrons and Auger electrons produced by low energy photons from either EBRT or brachytherapy sources with CaNPs and ONPs. Our results show a significant increase in the dose enhancement for various carboplatin and oxaliplatin concentrations up to their allowed FDA limits.

AB - Radiation boosting has been shown in a number of studies to be effective in the prevention of cancer recurrence. To further the effectiveness of this technique, we propose a new method of enhancing dose locally by administrating nanoparticles of carboplatin (CaNPs) and oxaliplatin (ONPs) as adjuvants to brachytherapy and external beam therapy (EBRT). To investigate the efficacy of this method, dose enhancement calculations were carried out to calculate the energy deposited by photoelectrons and Auger electrons produced by low energy photons from either EBRT or brachytherapy sources with CaNPs and ONPs. Our results show a significant increase in the dose enhancement for various carboplatin and oxaliplatin concentrations up to their allowed FDA limits.

KW - Carboplatin

KW - Concomitant chemoradiotherapy

KW - Dose enhancement

KW - Nano particles

KW - Oxaliplatin

UR - http://www.scopus.com/inward/record.url?scp=84944323218&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84944323218&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-19387-8_418

DO - 10.1007/978-3-319-19387-8_418

M3 - Conference contribution

AN - SCOPUS:84944323218

SN - 9783319193878

T3 - IFMBE Proceedings

SP - 1723

EP - 1726

BT - World Congress on Medical Physics and Biomedical Engineering, 2015

A2 - Jaffray, David A.

PB - Springer Verlag

T2 - World Congress on Medical Physics and Biomedical Engineering, 2015

Y2 - 7 June 2015 through 12 June 2015

ER -

Dose enhancement during concomitant chemoradiotherapy using FDA approved concentrations of carboplatin and oxaliplatin nanoparticles

Abstract

Publication series

Other

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this