Dopaminergic system does not play a major role in the precipitated cannabinoid withdrawal syndrome

M. Clara Sañudo-Peña, Michelle Force, Tsou Kang, Gabrielle McLemore, Langdon Roberts, J. Michael Walker

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


AIM: To determine the dopaminergic system involvement in precipitated cannabinoid withdrawal syndrome. METHODS: The dopamine D1 receptor antagonist SCH23390 or the dopamine D2 receptor antagonist sulpiride was administered to rats chronically treated with either Δ9- tetrahydrocannabinol (THC) or vehicle. Subjects were then injected with either SR141716A or vehicle and behavior was observed for 1 h. RESULTS: Administration of the cannabinoid receptor antagonist SR141716A to animals chronically treated with THC as described by Tsou et al (1995) produced a profound withdrawal syndrome. Treatment with dopamine antagonists did not attenuate cannabinoid precipitated withdrawal syndrome in THC tolerant animals while the agonists increased the syndrome. CONCLUSION: It is unlikely that the dopaminergic system plays a major role in mediating the behavioral aspects of the cannabinoid withdrawal syndrome.

Original languageEnglish (US)
Pages (from-to)1121-1124
Number of pages4
JournalActa Pharmacologica Sinica
Issue number12
StatePublished - 1999
Externally publishedYes


  • Cannabinoids
  • Dopamine antagonists
  • Dopamine D receptors
  • Dopamine D receptors
  • Pain
  • Pruritus
  • SR141716A
  • Substance withdrawal syndrome
  • Tetrahydrocannabinol

ASJC Scopus subject areas

  • General Chemistry
  • Pharmacology


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