Dopamine transporter SPECT imaging in parkinson disease and dementia

Devaki Shilpa Surasi; Patrick J. Peller; Zsolt Szabo; Gustavo Mercier; Rathan Subramaniam

doi:10.1016/j.cpet.2013.08.006

Dopamine transporter SPECT imaging in parkinson disease and dementia

Devaki Shilpa Surasi
, Patrick J. Peller
, Zsolt Szabo
, Gustavo Mercier
, Rathan Subramaniam

School of Medicine

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

The diagnosis of Parkinson disease (PD) and dementia with Lewy bodies (DLB) is often not straightforward. When PD symptoms are atypical or overlap with other diseases (eg, essential tremor [ET] or drug induced), [¹²³I] N-ω-fluoropropyl-2β-carbomethoxy-3b-(4-iodophenyl) nortropane ([ ¹²³I]FP-CIT) single-photon emission computed tomography (SPECT) can improve the diagnostic accuracy. The potential side effects of medications for PD may be avoided, if [¹²³I]FP-CIT SPECT is normal. [ ¹²³I]FP-CIT SPECT is helpful in the diagnosis of DLB, differentiating it from other causes of dementia such as Alzheimer disease (AD).

Original language	English (US)
Pages (from-to)	459-467
Number of pages	9
Journal	PET Clinics
Volume	8
Issue number	4
DOIs	https://doi.org/10.1016/j.cpet.2013.08.006
State	Published - Oct 2013

Keywords

Dementia
Dopamine
Parkinson disease
SPECT

ASJC Scopus subject areas

Radiation
Radiology Nuclear Medicine and imaging

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10.1016/j.cpet.2013.08.006

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@article{28b8e7b8620c4f42b994119f4b89194a,

title = "Dopamine transporter SPECT imaging in parkinson disease and dementia",

abstract = "The diagnosis of Parkinson disease (PD) and dementia with Lewy bodies (DLB) is often not straightforward. When PD symptoms are atypical or overlap with other diseases (eg, essential tremor [ET] or drug induced), [123I] N-ω-fluoropropyl-2β-carbomethoxy-3b-(4-iodophenyl) nortropane ([ 123I]FP-CIT) single-photon emission computed tomography (SPECT) can improve the diagnostic accuracy. The potential side effects of medications for PD may be avoided, if [123I]FP-CIT SPECT is normal. [ 123I]FP-CIT SPECT is helpful in the diagnosis of DLB, differentiating it from other causes of dementia such as Alzheimer disease (AD).",

keywords = "Dementia, Dopamine, Parkinson disease, SPECT",

author = "Surasi, \{Devaki Shilpa\} and Peller, \{Patrick J.\} and Zsolt Szabo and Gustavo Mercier and Rathan Subramaniam",

year = "2013",

month = oct,

doi = "10.1016/j.cpet.2013.08.006",

language = "English (US)",

volume = "8",

pages = "459--467",

journal = "PET Clinics",

issn = "1556-8598",

publisher = "W.B. Saunders",

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}

TY - JOUR

T1 - Dopamine transporter SPECT imaging in parkinson disease and dementia

AU - Surasi, Devaki Shilpa

AU - Peller, Patrick J.

AU - Szabo, Zsolt

AU - Mercier, Gustavo

AU - Subramaniam, Rathan

PY - 2013/10

Y1 - 2013/10

N2 - The diagnosis of Parkinson disease (PD) and dementia with Lewy bodies (DLB) is often not straightforward. When PD symptoms are atypical or overlap with other diseases (eg, essential tremor [ET] or drug induced), [123I] N-ω-fluoropropyl-2β-carbomethoxy-3b-(4-iodophenyl) nortropane ([ 123I]FP-CIT) single-photon emission computed tomography (SPECT) can improve the diagnostic accuracy. The potential side effects of medications for PD may be avoided, if [123I]FP-CIT SPECT is normal. [ 123I]FP-CIT SPECT is helpful in the diagnosis of DLB, differentiating it from other causes of dementia such as Alzheimer disease (AD).

AB - The diagnosis of Parkinson disease (PD) and dementia with Lewy bodies (DLB) is often not straightforward. When PD symptoms are atypical or overlap with other diseases (eg, essential tremor [ET] or drug induced), [123I] N-ω-fluoropropyl-2β-carbomethoxy-3b-(4-iodophenyl) nortropane ([ 123I]FP-CIT) single-photon emission computed tomography (SPECT) can improve the diagnostic accuracy. The potential side effects of medications for PD may be avoided, if [123I]FP-CIT SPECT is normal. [ 123I]FP-CIT SPECT is helpful in the diagnosis of DLB, differentiating it from other causes of dementia such as Alzheimer disease (AD).

KW - Dementia

KW - Dopamine

KW - Parkinson disease

KW - SPECT

UR - https://www.scopus.com/pages/publications/84885119235

UR - https://www.scopus.com/pages/publications/84885119235#tab=citedBy

U2 - 10.1016/j.cpet.2013.08.006

DO - 10.1016/j.cpet.2013.08.006

M3 - Review article

C2 - 27156473

AN - SCOPUS:84885119235

SN - 1556-8598

VL - 8

SP - 459

EP - 467

JO - PET Clinics

JF - PET Clinics

IS - 4

ER -

Dopamine transporter SPECT imaging in parkinson disease and dementia

Abstract

Keywords

ASJC Scopus subject areas

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