Dopamine transporter loss and clinical changes in MPTP-lesioned primates

Jamie L. Eberling; Krzysztof S. Bankiewicz; Phillip Pivirotto; John Bringas; Karen Chen; David P. Nowotnik; Joseph P. Steiner; Thomas F. Budinger; William J. Jagust

doi:10.1016/S0006-8993(99)01491-2

Dopamine transporter loss and clinical changes in MPTP-lesioned primates

Jamie L. Eberling, Krzysztof S. Bankiewicz, Phillip Pivirotto, John Bringas, Karen Chen, David P. Nowotnik, Joseph P. Steiner, Thomas F. Budinger, William J. Jagust

School of Medicine

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Single photon emission computed tomography (SPECT) and the dopamine (DA) transporter tracer, 2 beta-carboxymethoxy-3 beta-(4-iodophenyl)tropane ([¹²³I][β-CIT), were used to determine DA transporter density in 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned monkeys with varying degrees of parkinsonism. The clinical stage of parkinsonism corresponded to SPECT measures of striatal DA transporter density suggesting that more severe parkinsonism was associated with a greater degree of dopaminergic terminal degeneration. These findings are similar to those reported earlier using positron emission tomography (PET) and the DA metabolism tracer, 6-[¹⁸F]fluoro-L-m-tyrosine (FMT), indicating that both are good methods for evaluating nigrostriatal degeneration in MPTP primate models.

Original language	English (US)
Pages (from-to)	184-187
Number of pages	4
Journal	Brain research
Volume	832
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(99)01491-2
State	Published - Jun 19 1999

Keywords

Dopamine transporter
MPTP
Monkey
Parkinson's disease
Single photon emission computed tomography
β-CIT

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(99)01491-2

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title = "Dopamine transporter loss and clinical changes in MPTP-lesioned primates",

abstract = "Single photon emission computed tomography (SPECT) and the dopamine (DA) transporter tracer, 2 beta-carboxymethoxy-3 beta-(4-iodophenyl)tropane ([123I][β-CIT), were used to determine DA transporter density in 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned monkeys with varying degrees of parkinsonism. The clinical stage of parkinsonism corresponded to SPECT measures of striatal DA transporter density suggesting that more severe parkinsonism was associated with a greater degree of dopaminergic terminal degeneration. These findings are similar to those reported earlier using positron emission tomography (PET) and the DA metabolism tracer, 6-[18F]fluoro-L-m-tyrosine (FMT), indicating that both are good methods for evaluating nigrostriatal degeneration in MPTP primate models.",

keywords = "Dopamine transporter, MPTP, Monkey, Parkinson's disease, Single photon emission computed tomography, β-CIT",

author = "Eberling, {Jamie L.} and Bankiewicz, {Krzysztof S.} and Phillip Pivirotto and John Bringas and Karen Chen and Nowotnik, {David P.} and Steiner, {Joseph P.} and Budinger, {Thomas F.} and Jagust, {William J.}",

note = "Funding Information: This work was supported by a contract between Lawrence Berkeley National Laboratory and Guilford Pharmaceuticals, Agreement No. BG9805000. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.",

year = "1999",

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doi = "10.1016/S0006-8993(99)01491-2",

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AU - Bankiewicz, Krzysztof S.

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AU - Bringas, John

AU - Chen, Karen

AU - Nowotnik, David P.

AU - Steiner, Joseph P.

AU - Budinger, Thomas F.

AU - Jagust, William J.

N1 - Funding Information: This work was supported by a contract between Lawrence Berkeley National Laboratory and Guilford Pharmaceuticals, Agreement No. BG9805000. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.

PY - 1999/6/19

Y1 - 1999/6/19

N2 - Single photon emission computed tomography (SPECT) and the dopamine (DA) transporter tracer, 2 beta-carboxymethoxy-3 beta-(4-iodophenyl)tropane ([123I][β-CIT), were used to determine DA transporter density in 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned monkeys with varying degrees of parkinsonism. The clinical stage of parkinsonism corresponded to SPECT measures of striatal DA transporter density suggesting that more severe parkinsonism was associated with a greater degree of dopaminergic terminal degeneration. These findings are similar to those reported earlier using positron emission tomography (PET) and the DA metabolism tracer, 6-[18F]fluoro-L-m-tyrosine (FMT), indicating that both are good methods for evaluating nigrostriatal degeneration in MPTP primate models.

AB - Single photon emission computed tomography (SPECT) and the dopamine (DA) transporter tracer, 2 beta-carboxymethoxy-3 beta-(4-iodophenyl)tropane ([123I][β-CIT), were used to determine DA transporter density in 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned monkeys with varying degrees of parkinsonism. The clinical stage of parkinsonism corresponded to SPECT measures of striatal DA transporter density suggesting that more severe parkinsonism was associated with a greater degree of dopaminergic terminal degeneration. These findings are similar to those reported earlier using positron emission tomography (PET) and the DA metabolism tracer, 6-[18F]fluoro-L-m-tyrosine (FMT), indicating that both are good methods for evaluating nigrostriatal degeneration in MPTP primate models.

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Dopamine transporter loss and clinical changes in MPTP-lesioned primates

Abstract

Keywords

ASJC Scopus subject areas

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