TY - JOUR
T1 - Dopamine transporter dysfunction in Han Chinese people with chronic methamphetamine dependence after a short-term abstinence
AU - Yuan, Jie
AU - Lv, Rongbin
AU - Robert Brašić, James
AU - Han, Mei
AU - Liu, Xingdang
AU - Wang, Yuankai
AU - Zhang, Guangming
AU - Liu, Congjin
AU - Li, Yu
AU - Deng, Yanping
N1 - Funding Information:
This study was supported by a grant from the National Science and Technology Support Plan Project of China ( 2008BAI49B04 ).
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2014/1/30
Y1 - 2014/1/30
N2 - Single-photon emission-computed tomography (SPECT) after the administration of 99mTc-TRODAT-1 was performed on healthy subjects and subjects with methamphetamine (METH)dependence at time 1 (T1) after 24-48h of abstinence, time 2 (T2) after 2 weeks of abstinence, and time 3 (T3) after 4 weeks of abstinence. In contrast to values in controls, the values of the striatal DAT specific uptake ratios (SURs) in subjects with METH dependence were significantly lower at T1 (n=25), T2 (n=9), and T3 (n=8); a mild increase in SURs was observed at T2 and T3, but values were still significantly lower than those in controls. In subjects with METH dependence, there was a trend for a negative correlation of striatal DAT SURs and craving for METH at T1. METH craving, anxiety and depression scores significantly decreased from T1 to T2 to T3. We conclude that Han Chinese people with METH dependence experience significant striatal DAT dysfunction, and that these changes may be mildly reversible after 4 weeks of abstinence, but that DAT levels still remain significantly lower than those in healthy subjects. The mild recovery of striatal DAT may parallel improvements in craving, anxiety and depression.
AB - Single-photon emission-computed tomography (SPECT) after the administration of 99mTc-TRODAT-1 was performed on healthy subjects and subjects with methamphetamine (METH)dependence at time 1 (T1) after 24-48h of abstinence, time 2 (T2) after 2 weeks of abstinence, and time 3 (T3) after 4 weeks of abstinence. In contrast to values in controls, the values of the striatal DAT specific uptake ratios (SURs) in subjects with METH dependence were significantly lower at T1 (n=25), T2 (n=9), and T3 (n=8); a mild increase in SURs was observed at T2 and T3, but values were still significantly lower than those in controls. In subjects with METH dependence, there was a trend for a negative correlation of striatal DAT SURs and craving for METH at T1. METH craving, anxiety and depression scores significantly decreased from T1 to T2 to T3. We conclude that Han Chinese people with METH dependence experience significant striatal DAT dysfunction, and that these changes may be mildly reversible after 4 weeks of abstinence, but that DAT levels still remain significantly lower than those in healthy subjects. The mild recovery of striatal DAT may parallel improvements in craving, anxiety and depression.
KW - Dopamine transporter (DAT) tomography
KW - Emission-computed
KW - Methamphetamine (METH) abuse
KW - Single-photon
KW - Tc-TRODAT-1
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U2 - 10.1016/j.pscychresns.2013.11.005
DO - 10.1016/j.pscychresns.2013.11.005
M3 - Article
C2 - 24314908
AN - SCOPUS:84891829503
SN - 0925-4927
VL - 221
SP - 92
EP - 96
JO - Psychiatry Research - Neuroimaging
JF - Psychiatry Research - Neuroimaging
IS - 1
ER -