Dopamine receptors localised on cerebral cortical afferents to rat corpus striatum

Robert Schwarcz, Ian Creese, Joseph T. Coyle, Solomon H. Snyder

Research output: Contribution to journalArticlepeer-review

316 Scopus citations


STRIATAL dopamine receptors, monitored by dopamine-sensitive adenylate cyclase activity1,2 or binding of 3H-haloperidol 3-5 apparently represent distinct entities because of differences in drug sensitivity and the pattern of their ontogenetic development6,7. Dopamine also elicits both excitatory and inhibitory effects on striatal neurones8,9. We have examined the effects of selective degeneration of striatal intrinsic neurones with the neurotoxin. kainic acid10-12, and elimination of cortico-striate afferents by cortical ablation13 on the dopamine receptors in rat striatum. We present evidence that a substantial portion of striatal 3H-haloperidol receptor sites are localised to axons of cerebral cortical afferents whereas dopamine-sensitive adenylate cyclase is confined to neurones intrinsic to the striatum.

Original languageEnglish (US)
Pages (from-to)766-768
Number of pages3
Issue number5647
StatePublished - Jan 1 1978

ASJC Scopus subject areas

  • General


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