Dopamine receptors localised on cerebral cortical afferents to rat corpus striatum

Robert Schwarcz; Ian Creese; Joseph T. Coyle; Solomon H. Snyder

doi:10.1038/271766a0

Dopamine receptors localised on cerebral cortical afferents to rat corpus striatum

Robert Schwarcz, Ian Creese, Joseph T. Coyle, Solomon H. Snyder

School of Medicine

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316 Scopus citations

Abstract

STRIATAL dopamine receptors, monitored by dopamine-sensitive adenylate cyclase activity^1,2 or binding of ³H-haloperidol ^3-5 apparently represent distinct entities because of differences in drug sensitivity and the pattern of their ontogenetic development^6,7. Dopamine also elicits both excitatory and inhibitory effects on striatal neurones^8,9. We have examined the effects of selective degeneration of striatal intrinsic neurones with the neurotoxin. kainic acid^10-12, and elimination of cortico-striate afferents by cortical ablation¹³ on the dopamine receptors in rat striatum. We present evidence that a substantial portion of striatal ³H-haloperidol receptor sites are localised to axons of cerebral cortical afferents whereas dopamine-sensitive adenylate cyclase is confined to neurones intrinsic to the striatum.

Original language	English (US)
Pages (from-to)	766-768
Number of pages	3
Journal	Nature
Volume	271
Issue number	5647
DOIs	https://doi.org/10.1038/271766a0
State	Published - Jan 1 1978

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title = "Dopamine receptors localised on cerebral cortical afferents to rat corpus striatum",

abstract = "STRIATAL dopamine receptors, monitored by dopamine-sensitive adenylate cyclase activity1,2 or binding of 3H-haloperidol 3-5 apparently represent distinct entities because of differences in drug sensitivity and the pattern of their ontogenetic development6,7. Dopamine also elicits both excitatory and inhibitory effects on striatal neurones8,9. We have examined the effects of selective degeneration of striatal intrinsic neurones with the neurotoxin. kainic acid10-12, and elimination of cortico-striate afferents by cortical ablation13 on the dopamine receptors in rat striatum. We present evidence that a substantial portion of striatal 3H-haloperidol receptor sites are localised to axons of cerebral cortical afferents whereas dopamine-sensitive adenylate cyclase is confined to neurones intrinsic to the striatum.",

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AU - Schwarcz, Robert

AU - Creese, Ian

AU - Coyle, Joseph T.

AU - Snyder, Solomon H.

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AB - STRIATAL dopamine receptors, monitored by dopamine-sensitive adenylate cyclase activity1,2 or binding of 3H-haloperidol 3-5 apparently represent distinct entities because of differences in drug sensitivity and the pattern of their ontogenetic development6,7. Dopamine also elicits both excitatory and inhibitory effects on striatal neurones8,9. We have examined the effects of selective degeneration of striatal intrinsic neurones with the neurotoxin. kainic acid10-12, and elimination of cortico-striate afferents by cortical ablation13 on the dopamine receptors in rat striatum. We present evidence that a substantial portion of striatal 3H-haloperidol receptor sites are localised to axons of cerebral cortical afferents whereas dopamine-sensitive adenylate cyclase is confined to neurones intrinsic to the striatum.

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Dopamine receptors localised on cerebral cortical afferents to rat corpus striatum

Abstract

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