Dopamine receptor excess and mouse madness

Research output: Contribution to journalShort surveypeer-review

27 Scopus citations


The dopamine hypothesis of schizophrenia is based on evidence that the major antipsychotic drugs act by blocking dopamine D2 receptors and that dopamine-releasing drugs worsen symptoms. In this issue of Neuron, Kellendonk et al. report an elegant conditional transgenic mouse overexpressing dopamine D2 receptors selectively in the striatum. Strikingly, these animals display selective cognitive impairment typically associated with frontal cortical defects and abnormal dopamine markers in the prefrontal cortex, suggesting that striatal dopamine receptors can influence cortical dopamine function.

Original languageEnglish (US)
Pages (from-to)484-485
Number of pages2
Issue number4
StatePublished - Feb 16 2006

ASJC Scopus subject areas

  • Neuroscience(all)


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