Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs

I. Creese; D. R. Burt; S. H. Snyder

doi:10.1176/jnp.8.2.223

Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs

I. Creese, D. R. Burt, S. H. Snyder

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Tritiated haloperidol and tritiated dopamine label postsynaptic dopamine receptors in mammalian brain. Clinical potencies of butyrophenones, phenothiazines, and related drugs correlate closely with their ability to inhibit tritiated haloperidol binding. These binding methods provide a simple in vitro means for evaluating new drugs as potential antischizophrenic agents.

Original language	English (US)
Pages (from-to)	223-226
Number of pages	4
Journal	Journal of Neuropsychiatry and Clinical Neurosciences
Volume	8
Issue number	2
DOIs	https://doi.org/10.1176/jnp.8.2.223
State	Published - Jan 1 1996
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

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10.1176/jnp.8.2.223

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abstract = "Tritiated haloperidol and tritiated dopamine label postsynaptic dopamine receptors in mammalian brain. Clinical potencies of butyrophenones, phenothiazines, and related drugs correlate closely with their ability to inhibit tritiated haloperidol binding. These binding methods provide a simple in vitro means for evaluating new drugs as potential antischizophrenic agents.",

author = "I. Creese and Burt, {D. R.} and Snyder, {S. H.}",

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AB - Tritiated haloperidol and tritiated dopamine label postsynaptic dopamine receptors in mammalian brain. Clinical potencies of butyrophenones, phenothiazines, and related drugs correlate closely with their ability to inhibit tritiated haloperidol binding. These binding methods provide a simple in vitro means for evaluating new drugs as potential antischizophrenic agents.

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Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs

Abstract

ASJC Scopus subject areas

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