TY - JOUR
T1 - Dopamine D2 receptors in WFS1-neurons regulate food-seeking and avoidance behaviors
AU - Castell, Laia
AU - Le Gall, Valentine
AU - Cutando, Laura
AU - Petit, Chloé P.
AU - Puighermanal, Emma
AU - Makrini-Maleville, Leila
AU - Kim, Ha Rang
AU - Jercog, Daniel
AU - Tarot, Pauline
AU - Tassou, Adrien
AU - Harrus, Anne Gabrielle
AU - Rubinstein, Marcelo
AU - Nouvian, Régis
AU - Rivat, Cyril
AU - Besnard, Antoine
AU - Trifilieff, Pierre
AU - Gangarossa, Giuseppe
AU - Janak, Patricia H.
AU - Herry, Cyril
AU - Valjent, Emmanuel
N1 - Publisher Copyright:
© 2023
PY - 2024/2/8
Y1 - 2024/2/8
N2 - The selection and optimization of appropriate adaptive responses depends on interoceptive and exteroceptive stimuli as well as on the animal's ability to switch from one behavioral strategy to another. Although growing evidence indicate that dopamine D2R-mediated signaling events ensure the selection of the appropriate strategy for each specific situation, the underlying neural circuits through which they mediate these effects are poorly characterized. Here, we investigated the role of D2R signaling in a mesolimbic neuronal subpopulation expressing the Wolfram syndrome 1 (Wfs1) gene. This subpopulation is located within the nucleus accumbens, the central amygdala, the bed nucleus of the stria terminalis, and the tail of the striatum, all brain regions critical for the regulation of emotions and motivated behaviors. Using a mouse model carrying a temporally controlled deletion of D2R in WFS1-neurons, we demonstrate that intact D2R signaling in this neuronal population is necessary to regulate homeostasis-dependent food-seeking behaviors in both male and female mice. In addition, we found that reduced D2R signaling in WFS1-neurons impaired active avoidance learning and innate escape responses. Collectively, these findings identify a yet undocumented role for D2R signaling in WFS1-neurons as a novel effector through which dopamine optimizes appetitive behaviors and regulates defensive behaviors.
AB - The selection and optimization of appropriate adaptive responses depends on interoceptive and exteroceptive stimuli as well as on the animal's ability to switch from one behavioral strategy to another. Although growing evidence indicate that dopamine D2R-mediated signaling events ensure the selection of the appropriate strategy for each specific situation, the underlying neural circuits through which they mediate these effects are poorly characterized. Here, we investigated the role of D2R signaling in a mesolimbic neuronal subpopulation expressing the Wolfram syndrome 1 (Wfs1) gene. This subpopulation is located within the nucleus accumbens, the central amygdala, the bed nucleus of the stria terminalis, and the tail of the striatum, all brain regions critical for the regulation of emotions and motivated behaviors. Using a mouse model carrying a temporally controlled deletion of D2R in WFS1-neurons, we demonstrate that intact D2R signaling in this neuronal population is necessary to regulate homeostasis-dependent food-seeking behaviors in both male and female mice. In addition, we found that reduced D2R signaling in WFS1-neurons impaired active avoidance learning and innate escape responses. Collectively, these findings identify a yet undocumented role for D2R signaling in WFS1-neurons as a novel effector through which dopamine optimizes appetitive behaviors and regulates defensive behaviors.
KW - Dopamine
KW - Extended amygdala
KW - Motivated behaviors
KW - Neural circuit
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U2 - 10.1016/j.pnpbp.2023.110883
DO - 10.1016/j.pnpbp.2023.110883
M3 - Article
C2 - 37858736
AN - SCOPUS:85174716147
SN - 0278-5846
VL - 129
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
M1 - 110883
ER -