DOET(2,5-Dimethoxy-4-Ethylamphetamine), a New Psychotropic Drug: Effects of Varying Doses in Man

Solomon H. Snyder, Herbert Weingartner, Louis A. Faillace

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


DOET (2,5-dimethoxy-4-ethylamphetamine) is a new psychotropic agent which chemically resembles mescaline and amphetamine. It is essentially the ethyl homologue of DOM (2,5-dimethoxy-4-methylamphetamine), a psychotomimetic drug widely used by hippie populations and designated “STP.” DOET was administered to normal male subjects in doses ranging from 0.75 to 4 mg and contrasted with effects of a water placebo. In all cases DOET produced subjective effects including a mild euphoria, a feeling of enhanced self-awareness, and a tendency to feel “anxious” at higher doses. Although there was some increase in subjective effects at higher doses, this was not marked. No hallucinogenic or psychotomimetic effects were observed at any dose. Thus, over a five-fold range of pharmacologically active dosage, the “enhanced awareness” produced by DOET was not associated with psychotomimetic or hallucinogenic actions.

Original languageEnglish (US)
Pages (from-to)50-55
Number of pages6
JournalArchives of general psychiatry
Issue number1
StatePublished - Jan 1971

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health


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