Does the proteome encode organellar pH?

Christopher L. Brett, Mark Donowitz, Rajini Rao

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Inherent to the proteome itself, may be information that enables proteins to buffer pH at a level that promotes their own function within a specialized compartment. We observe that the distribution of computed isoelectric points in the yeast proteome matches experimentally derived organellar pH estimates across distinct subcellular compartments. This raises an interesting evolutionary question: did the pI of proteins and the pH of organelles co-evolve to optimize function?

Original languageEnglish (US)
Pages (from-to)717-719
Number of pages3
JournalFEBS Letters
Issue number3
StatePublished - Feb 6 2006


  • Evolution
  • Proteome
  • Subcellular compartment
  • Yeast
  • pH
  • pI

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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