Does perineural invasion on prostate biopsy predict adverse prostatectomy outcomes?

Stacy Loeb, Jonathan I. Epstein, Elizabeth B. Humphreys, Patrick C. Walsh

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


Study Type - Prognostic (case series) Level of Evidence 4 Objective To determine the relationship between perineural invasion (PNI) on prostate biopsy and radical prostatectomy (RP) outcomes in a contemporary RP series, as there is conflicting evidence on the prognostic significance of PNI in prostate needle biopsy specimens. Patients and Methods From 2002 to 2007, 1256 men had RP by one surgeon. Multivariable logistic regression and Cox proportional hazards models were used to examine the relationship of PNI with pathological tumour features and biochemical progression, respectively, after adjusting for prostate-specific antigen level, clinical stage and biopsy Gleason score. Additional Cox models were used to examine the relationship between nerve-sparing and biochemical progression among men with PNI. Results PNI was found in 188 (15%) patients, and was significantly associated with aggressive pathology and biochemical progression. On multivariate analysis, PNI was significantly associated with extraprostatic extension and seminal vesicle invasion (P < 0.001). Biochemical progression occurred in 10.5% of patients with PNI, vs 3.5% of those without PNI (unadjusted hazard ratio 3.12, 95% confidence interval 1.77-5.52, P < 0.001). However, PNI was not a significant independent predictor of biochemical progression on multivariate analysis. Finally, nerve-sparing did not adversely affect biochemical progression even among men with PNI. Conclusion PNI is an independent risk factor for aggressive pathology features and a non-independent risk factor for biochemical progression after RP. However, bilateral nerve-sparing surgery did not compromise the oncological outcomes for patients with PNI on biopsy.

Original languageEnglish (US)
Pages (from-to)1510-1513
Number of pages4
JournalBJU International
Issue number11
StatePublished - Jun 2010


  • Outcomes
  • Perineural invasion
  • Prostate biopsy
  • Prostate cancer
  • Radical prostatectomy

ASJC Scopus subject areas

  • Urology


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