Does midtrimester cervical length ≥25 mm predict preterm birth in high-risk women?

John Owen, Jeff M. Szychowski, Gary Hankins, Jay D. Iams, Jeanne S. Sheffield, Annette Perez-Delboy, Vincenzo Berghella, Deborah A. Wing, Edwin R. Guzman

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Objective: We sought to assess pregnancy outcome along a continuum of cervical lengths (CLs) ≥25 mm. Study Design: We conducted planned secondary analysis of a randomized cerclage trial of women with prior spontaneous preterm birth 170-346/7 weeks. Outcomes of women who maintained CLs ≥25 mm were analyzed. Women with CLs <25 mm randomized to no cerclage comprised an internal comparison group. Results: Of 1014 screened, 153 had CL <25 mm, and 672 had CL ≥25 mm. Birth <35 weeks occurred in 16% of the ≥25 mm cohort. The relationship between CLs ≥25 mm and birth gestational age was null (P = .15). In the <25 mm group, progressively shorter CLs predicted birth <35 weeks (P < .001); this relationship was null in the ≥25 mm group (P = .17). Conclusion: The continuum of CLs ≥25 mm measured between 160/7-226/7 weeks does not predict gestational length in women with prior spontaneous preterm birth.

Original languageEnglish (US)
Pages (from-to)393.e1-393.e5
JournalAmerican journal of obstetrics and gynecology
Issue number4
StatePublished - Oct 2010
Externally publishedYes


  • cervical length
  • preterm birth prediction
  • prior preterm birth
  • vaginal sonography

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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