Does adjuvant chemotherapy improve survival for women with early-stage uterine leiomyosarcoma?

Stephanie Ricci, Robert L. Giuntoli, Eric Eisenhauer, Micael A. Lopez, Lauren Krill, Edward J. Tanner, Paola A. Gehrig, Laura J. Havrilesky, Angeles Alvarez Secord, Kimberly Levinson, Heidi Frasure, Paul Celano, Amanda Nickles Fader

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Objectives To examine whether adjuvant therapy after primary surgery for treatment of early-stage uterine leiomyosarcoma (LMS) improves recurrence and survival rates. Methods A multisite, retrospective study of women diagnosed with stage I-II high grade LMS from 1990-2010 was performed. All patients (pts) underwent primary surgery followed by observation (OBS), radiotherapy (RT), or chemotherapy (CT) postoperatively. Results One hundred eight patients were identified with long-term follow-up; 94 pts (87.0%) had stage I and 14 (13.0%) had stage II disease. The mean patient age was 55.4 years and mean BMI was 28.0. Thirty-four (31.5%) patients underwent OBS, 35 (32.4%) received RT, and 39 (36.1%) received chemotherapy. After a median follow-up of 41.8 months, a recurrence was diagnosed in 70.8%. Recurrence was evident in 25/34 (73.5%) OBS, 23/35 (65.7%) RT, and 28/39 (71.8%) of CT cohorts and was not different based on treatment (p = 0.413). However, extra-pelvic recurrences were significantly higher in the RT (95.2%) than in the OBS (60%) or CT (64.3%) cohorts (p = 0.012). Additionally, recurrences were more likely to be successfully treated or palliated in those who initially received CT (p = 0.031). On multivariate analysis, stage (p < 0.001) and chemotherapy (p = 0.045) were associated with overall survival. Conclusions Women with early-stage, high grade uterine LMS experience high recurrence rates and poor survival outcomes, irrespective of adjuvant therapy. These rates are higher than previously reported in the literature. Although women treated with CT had similar recurrence rates as those treated with OBS or RT, treatment with adjuvant chemotherapy may decrease the risk of extra-pelvic recurrence and improve survival.

Original languageEnglish (US)
Pages (from-to)629-633
Number of pages5
JournalGynecologic oncology
Issue number3
StatePublished - Dec 2013


  • Adjuvant therapy
  • Chemotherapy
  • Uterine leiomyosarcoma

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology


Dive into the research topics of 'Does adjuvant chemotherapy improve survival for women with early-stage uterine leiomyosarcoma?'. Together they form a unique fingerprint.

Cite this