TY - JOUR
T1 - DNA sequence–directed shape change of photopatterned hydrogels via high-degree swelling
AU - Cangialosi, Angelo
AU - Yoon, Chang Kyu
AU - Liu, Jiayu
AU - Huang, Qi
AU - Guo, Jingkai
AU - Nguyen, Thao D.
AU - Gracias, David H.
AU - Schulman, Rebecca
N1 - Publisher Copyright:
© 2017, American Association for the Advancement of Science. All rights reserved.
PY - 2017/9/15
Y1 - 2017/9/15
N2 - Shape-changing hydrogels that can bend, twist, or actuate in response to external stimuli are critical to soft robots, programmable matter, and smart medicine. Shape change in hydrogels has been induced by global cues, including temperature, light, or pH. Here we demonstrate that specific DNA molecules can induce 100-fold volumetric hydrogel expansion by successive extension of cross-links. We photopattern up to centimeter-sized gels containing multiple domains that undergo different shape changes in response to different DNA sequences. Experiments and simulations suggest a simple design rule for controlled shape change. Because DNA molecules can be coupled to molecular sensors, amplifiers, and logic circuits, this strategy introduces the possibility of building soft devices that respond to diverse biochemical inputs and autonomously implement chemical control programs.
AB - Shape-changing hydrogels that can bend, twist, or actuate in response to external stimuli are critical to soft robots, programmable matter, and smart medicine. Shape change in hydrogels has been induced by global cues, including temperature, light, or pH. Here we demonstrate that specific DNA molecules can induce 100-fold volumetric hydrogel expansion by successive extension of cross-links. We photopattern up to centimeter-sized gels containing multiple domains that undergo different shape changes in response to different DNA sequences. Experiments and simulations suggest a simple design rule for controlled shape change. Because DNA molecules can be coupled to molecular sensors, amplifiers, and logic circuits, this strategy introduces the possibility of building soft devices that respond to diverse biochemical inputs and autonomously implement chemical control programs.
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U2 - 10.1126/science.aan3925
DO - 10.1126/science.aan3925
M3 - Article
C2 - 28912239
AN - SCOPUS:85029477421
SN - 0036-8075
VL - 357
SP - 1126
EP - 1130
JO - Science
JF - Science
IS - 6356
ER -