TY - JOUR
T1 - Dna repair and susceptibility to basal cell carcinoma
T2 - A case-control study
AU - Wei, Qingyi
AU - Matanoski, Genevieve M.
AU - Farmer, Evan R.
AU - Hedayati, Mohammad A.
AU - Grossman, Lawrence
N1 - Funding Information:
This research was supported by National Institutes of Health grant RO1-GM31110 (to L. G.) and National Institute of Environmental Health grant P30-ESO3819 (to G. M. M.). The authors are grateful to Drs. Paul Strickland, Margaret Spitz, and Christopher Amos for their comments and suggestions, to Deborah Landry for her assistance in the recruiting of subjects, and to Dr. Maureen Goode for her editorial help in the preparation of the manuscript.
PY - 1994/10/1
Y1 - 1994/10/1
N2 - This study investigated the role of DNA repair in susceptibility to sunlight-induced basal cell carcinoma using a host cell reactivation assay in peripheral lymphocytes. The study included Maryland basal cell carcinoma patients and cancer-free derma tologic controls who had had noncancerous skin disorders diagnosed between 1987 and 1990. Logistic regression models were used to assess the independent effect of the selected variables stratified by DNA repair level, with adjustment for age and family history. Skin type, lifetime number of severe sunburns, and actinic elastosis were also selected as risk factors for basal cell carcinoma. Cryopreserved lymphocytes from 88 cases and 135 controls were used for the DNA repair assay. When data were stratified by DNA repair level and adjusted for age and family history of skin cancer, significantly increased odds ratios associated with lighter skin (odds ratio (OR) = 3.2, 95% confidence interval (Cl) 1.5-7.3), six or more severe sunburns in a lifetime (OR = 4.2, 95% Cl 1.6-10.7), and moderate or severe actinic elastosis (OR = 4.4, 95% Cl 1.5-12.8) were observed in persons with low DNA repair but not in those with high DNA repair. These findings suggest that impaired DNA repair may be a susceptibility factor for sunlight-induced skin cancer in the general public, as it is in patients with xeroderma pigmentosum.
AB - This study investigated the role of DNA repair in susceptibility to sunlight-induced basal cell carcinoma using a host cell reactivation assay in peripheral lymphocytes. The study included Maryland basal cell carcinoma patients and cancer-free derma tologic controls who had had noncancerous skin disorders diagnosed between 1987 and 1990. Logistic regression models were used to assess the independent effect of the selected variables stratified by DNA repair level, with adjustment for age and family history. Skin type, lifetime number of severe sunburns, and actinic elastosis were also selected as risk factors for basal cell carcinoma. Cryopreserved lymphocytes from 88 cases and 135 controls were used for the DNA repair assay. When data were stratified by DNA repair level and adjusted for age and family history of skin cancer, significantly increased odds ratios associated with lighter skin (odds ratio (OR) = 3.2, 95% confidence interval (Cl) 1.5-7.3), six or more severe sunburns in a lifetime (OR = 4.2, 95% Cl 1.6-10.7), and moderate or severe actinic elastosis (OR = 4.4, 95% Cl 1.5-12.8) were observed in persons with low DNA repair but not in those with high DNA repair. These findings suggest that impaired DNA repair may be a susceptibility factor for sunlight-induced skin cancer in the general public, as it is in patients with xeroderma pigmentosum.
KW - Basal cell
KW - Biological markers
KW - Carcinoma
KW - Case-control studies
KW - DNA repair
KW - Skinneoplasms
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U2 - 10.1093/oxfordjournals.aje.a117297
DO - 10.1093/oxfordjournals.aje.a117297
M3 - Article
C2 - 7942760
AN - SCOPUS:0027939189
SN - 0002-9262
VL - 140
SP - 598
EP - 607
JO - American journal of epidemiology
JF - American journal of epidemiology
IS - 7
ER -