DNA methylation signatures as biomarkers of socioeconomic position

Meghna Rajaprakash; Lorraine T. Dean; Meredith Palmore; Sara B. Johnson; Joan Kaufman; Daniele M. Fallin; Christine Ladd-Acosta

doi:10.1093/eep/dvac027

DNA methylation signatures as biomarkers of socioeconomic position

Meghna Rajaprakash, Lorraine T. Dean, Meredith Palmore, Sara B. Johnson, Joan Kaufman, Daniele M. Fallin, Christine Ladd-Acosta

Research output: Contribution to journal › Review article › peer-review

Abstract

This review article provides a framework for the use of deoxyribonucleic acid (DNA) methylation (DNAm) biomarkers to study the biological embedding of socioeconomic position (SEP) and summarizes the latest developments in the area. It presents the emerging literature showing associations between individual- and neighborhood-level SEP exposures and DNAm across the life course. In contrast to questionnaire-based methods of assessing SEP, we suggest that DNAm biomarkers may offer an accessible metric to study questions about SEP and health outcomes, acting as a personal dosimeter of exposure. However, further work remains in standardizing SEP measures across studies and evaluating consistency across domains, tissue types, and time periods. Meta-analyses of epigenetic associations with SEP are offered as one approach to confirm the replication of DNAm loci across studies. The development of DNAm biomarkers of SEP would provide a method for examining its impact on health outcomes in a more robust way, increasing the rigor of epidemiological studies.

Original language	English (US)
Article number	dvac027
Journal	Environmental Epigenetics
Volume	9
Issue number	1
DOIs	https://doi.org/10.1093/eep/dvac027
State	Published - 2023

Keywords

DNA methylation
EWAS
biomarker
social epigenomics
socioeconomic position

ASJC Scopus subject areas

Genetics(clinical)
Genetics
Molecular Biology
Health, Toxicology and Mutagenesis

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10.1093/eep/dvac027

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title = "DNA methylation signatures as biomarkers of socioeconomic position",

abstract = "This review article provides a framework for the use of deoxyribonucleic acid (DNA) methylation (DNAm) biomarkers to study the biological embedding of socioeconomic position (SEP) and summarizes the latest developments in the area. It presents the emerging literature showing associations between individual- and neighborhood-level SEP exposures and DNAm across the life course. In contrast to questionnaire-based methods of assessing SEP, we suggest that DNAm biomarkers may offer an accessible metric to study questions about SEP and health outcomes, acting as a personal dosimeter of exposure. However, further work remains in standardizing SEP measures across studies and evaluating consistency across domains, tissue types, and time periods. Meta-analyses of epigenetic associations with SEP are offered as one approach to confirm the replication of DNAm loci across studies. The development of DNAm biomarkers of SEP would provide a method for examining its impact on health outcomes in a more robust way, increasing the rigor of epidemiological studies.",

keywords = "DNA methylation, EWAS, biomarker, social epigenomics, socioeconomic position",

author = "Meghna Rajaprakash and Dean, {Lorraine T.} and Meredith Palmore and Johnson, {Sara B.} and Joan Kaufman and Fallin, {Daniele M.} and Christine Ladd-Acosta",

note = "Funding Information: Dr Ladd-Acosta reports receiving consulting fees from the University of Iowa for providing expertise on epigenetics outside of this work. Dr Kaufman has received grant funding from the NIH, has served as a consultant for Pfizer and Otsuka Pharmaceuticals, and has a proprietary financial interest in the computer-administered KSADS (KSADS-COMP, LLC). Funding Information: Drs Ladd-Acosta and Dean{\textquoteright}s contributions were supported by funding from the National Institute on Minority Health and Health Disparities (R01MD015407; PI: Ladd-Acosta). Drs Johnson and Kaufman{\textquoteright}s contributions were supported by the National Institute on Minority Health and Health Disparities (NIMHD; R01 MD011746; Kaufman; Johnson). Publisher Copyright: {\textcopyright} The Author(s) 2023. Published by Oxford University Press.",

year = "2023",

doi = "10.1093/eep/dvac027",

language = "English (US)",

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journal = "Environmental Epigenetics",

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AU - Rajaprakash, Meghna

AU - Dean, Lorraine T.

AU - Palmore, Meredith

AU - Johnson, Sara B.

AU - Kaufman, Joan

AU - Fallin, Daniele M.

AU - Ladd-Acosta, Christine

N1 - Funding Information: Dr Ladd-Acosta reports receiving consulting fees from the University of Iowa for providing expertise on epigenetics outside of this work. Dr Kaufman has received grant funding from the NIH, has served as a consultant for Pfizer and Otsuka Pharmaceuticals, and has a proprietary financial interest in the computer-administered KSADS (KSADS-COMP, LLC). Funding Information: Drs Ladd-Acosta and Dean’s contributions were supported by funding from the National Institute on Minority Health and Health Disparities (R01MD015407; PI: Ladd-Acosta). Drs Johnson and Kaufman’s contributions were supported by the National Institute on Minority Health and Health Disparities (NIMHD; R01 MD011746; Kaufman; Johnson). Publisher Copyright: © The Author(s) 2023. Published by Oxford University Press.

PY - 2023

Y1 - 2023

N2 - This review article provides a framework for the use of deoxyribonucleic acid (DNA) methylation (DNAm) biomarkers to study the biological embedding of socioeconomic position (SEP) and summarizes the latest developments in the area. It presents the emerging literature showing associations between individual- and neighborhood-level SEP exposures and DNAm across the life course. In contrast to questionnaire-based methods of assessing SEP, we suggest that DNAm biomarkers may offer an accessible metric to study questions about SEP and health outcomes, acting as a personal dosimeter of exposure. However, further work remains in standardizing SEP measures across studies and evaluating consistency across domains, tissue types, and time periods. Meta-analyses of epigenetic associations with SEP are offered as one approach to confirm the replication of DNAm loci across studies. The development of DNAm biomarkers of SEP would provide a method for examining its impact on health outcomes in a more robust way, increasing the rigor of epidemiological studies.

AB - This review article provides a framework for the use of deoxyribonucleic acid (DNA) methylation (DNAm) biomarkers to study the biological embedding of socioeconomic position (SEP) and summarizes the latest developments in the area. It presents the emerging literature showing associations between individual- and neighborhood-level SEP exposures and DNAm across the life course. In contrast to questionnaire-based methods of assessing SEP, we suggest that DNAm biomarkers may offer an accessible metric to study questions about SEP and health outcomes, acting as a personal dosimeter of exposure. However, further work remains in standardizing SEP measures across studies and evaluating consistency across domains, tissue types, and time periods. Meta-analyses of epigenetic associations with SEP are offered as one approach to confirm the replication of DNAm loci across studies. The development of DNAm biomarkers of SEP would provide a method for examining its impact on health outcomes in a more robust way, increasing the rigor of epidemiological studies.

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DNA methylation signatures as biomarkers of socioeconomic position

Abstract

Keywords

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