DNA methylation, molecular genetic, and linkage studies in prostate cancer.

D. F. Jarrard, G. S. Bova, W. B. Isaacs

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Molecular biologic studies have now identified a number of important genetic and epigenetic mechanisms that cause alterations in growth and differentiation genes in prostate cancer. In addition to DNA deletion and point mutation, DNA methylation represents a new paradigm for the inactivation of tumor suppressor or growth suppressor genes. The identification of new genes, including a prostate cancer susceptibility locus, may furnish further insight into the molecular characteristics of prostate cancer and permit the early identification of affected individuals.

Original languageEnglish (US)
Pages (from-to)36-44
Number of pages9
JournalThe Prostate. Supplement
StatePublished - 1996

ASJC Scopus subject areas

  • General Medicine


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