Abstract
Molecular biologic studies have now identified a number of important genetic and epigenetic mechanisms that cause alterations in growth and differentiation genes in prostate cancer. In addition to DNA deletion and point mutation, DNA methylation represents a new paradigm for the inactivation of tumor suppressor or growth suppressor genes. The identification of new genes, including a prostate cancer susceptibility locus, may furnish further insight into the molecular characteristics of prostate cancer and permit the early identification of affected individuals.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 36-44 |
| Number of pages | 9 |
| Journal | The Prostate. Supplement |
| Volume | 6 |
| State | Published - 1996 |
ASJC Scopus subject areas
- General Medicine