Diversity counts: Visualizing pretumor progression in the gastrointestinal tract

Danielle Langeveld; Marnix Jansen; Lodewijk Brosens; Folkert Morsink; G. Johan Offerhaus; Wendy De Leng

doi:10.1309/AJCPP3I5HDYWMHJA

Diversity counts: Visualizing pretumor progression in the gastrointestinal tract

Danielle Langeveld, Marnix Jansen, Lodewijk Brosens, Folkert Morsink, G. Johan Offerhaus, Wendy De Leng

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Tumor progression is critically dependent on the selection of genetic alterations. This clonal evolution can be traced to the stage preceding visible tumor formation called pretumor progression, in which genetic change occurs without visible change. Recently, the identification of intestinal stem cell markers in animal models has made visualization of stem cells possible in vivo. Translating this work to the clinical setting by visualizing stem cells in patient material may allow us to understand differences in patients' vulnerability to cancer development and target preventive measures to high-risk groups. In this review article, we examine some of the analytic methods currently used in research settings tracing stem cell dynamics.

Original language	English (US)
Pages (from-to)	878-888
Number of pages	11
Journal	American Journal of Clinical Pathology
Volume	135
Issue number	6
DOIs	https://doi.org/10.1309/AJCPP3I5HDYWMHJA
State	Published - Jun 2011
Externally published	Yes

Keywords

Gastrointestinal tract neoplasms
Genetic alterations
Genetic diversity
Intestinal stem cell markers
Pretumor progression
Prevention
Risk
Tumor progression

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1309/AJCPP3I5HDYWMHJA

Cite this

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title = "Diversity counts: Visualizing pretumor progression in the gastrointestinal tract",

abstract = "Tumor progression is critically dependent on the selection of genetic alterations. This clonal evolution can be traced to the stage preceding visible tumor formation called pretumor progression, in which genetic change occurs without visible change. Recently, the identification of intestinal stem cell markers in animal models has made visualization of stem cells possible in vivo. Translating this work to the clinical setting by visualizing stem cells in patient material may allow us to understand differences in patients' vulnerability to cancer development and target preventive measures to high-risk groups. In this review article, we examine some of the analytic methods currently used in research settings tracing stem cell dynamics.",

keywords = "Gastrointestinal tract neoplasms, Genetic alterations, Genetic diversity, Intestinal stem cell markers, Pretumor progression, Prevention, Risk, Tumor progression",

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year = "2011",

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AU - Langeveld, Danielle

AU - Jansen, Marnix

AU - Brosens, Lodewijk

AU - Morsink, Folkert

AU - Offerhaus, G. Johan

AU - De Leng, Wendy

PY - 2011/6

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AB - Tumor progression is critically dependent on the selection of genetic alterations. This clonal evolution can be traced to the stage preceding visible tumor formation called pretumor progression, in which genetic change occurs without visible change. Recently, the identification of intestinal stem cell markers in animal models has made visualization of stem cells possible in vivo. Translating this work to the clinical setting by visualizing stem cells in patient material may allow us to understand differences in patients' vulnerability to cancer development and target preventive measures to high-risk groups. In this review article, we examine some of the analytic methods currently used in research settings tracing stem cell dynamics.

KW - Gastrointestinal tract neoplasms

KW - Genetic alterations

KW - Genetic diversity

KW - Intestinal stem cell markers

KW - Pretumor progression

KW - Prevention

KW - Risk

KW - Tumor progression

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Diversity counts: Visualizing pretumor progression in the gastrointestinal tract

Abstract

Keywords

ASJC Scopus subject areas

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