Diversity counts: Visualizing pretumor progression in the gastrointestinal tract

Danielle Langeveld, Marnix Jansen, Lodewijk Brosens, Folkert Morsink, G. Johan Offerhaus, Wendy De Leng

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Tumor progression is critically dependent on the selection of genetic alterations. This clonal evolution can be traced to the stage preceding visible tumor formation called pretumor progression, in which genetic change occurs without visible change. Recently, the identification of intestinal stem cell markers in animal models has made visualization of stem cells possible in vivo. Translating this work to the clinical setting by visualizing stem cells in patient material may allow us to understand differences in patients' vulnerability to cancer development and target preventive measures to high-risk groups. In this review article, we examine some of the analytic methods currently used in research settings tracing stem cell dynamics.

Original languageEnglish (US)
Pages (from-to)878-888
Number of pages11
JournalAmerican Journal of Clinical Pathology
Issue number6
StatePublished - Jun 2011
Externally publishedYes


  • Gastrointestinal tract neoplasms
  • Genetic alterations
  • Genetic diversity
  • Intestinal stem cell markers
  • Pretumor progression
  • Prevention
  • Risk
  • Tumor progression

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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