Divergent roles of autophagy in virus infection

Abhilash I. Chiramel, Nathan R. Brady, Ralf Bartenschlager

Research output: Contribution to journalReview articlepeer-review


Viruses have played an important role in human evolution and have evolved diverse strategies to co-exist with their hosts. As obligate intracellular pathogens, viruses exploit and manipulate different host cell processes, including cellular trafficking, metabolism and immunity-related functions, for their own survival. In this article, we review evidence for how autophagy, a highly conserved cellular degradative pathway, serves either as an antiviral defense mechanism or, alternatively, as a pro-viral process during virus infection. Furthermore, we highlight recent reports concerning the role of selective autophagy in virus infection and how viruses manipulate autophagy to evade lysosomal capture and degradation.

Original languageEnglish (US)
Pages (from-to)83-104
Number of pages22
Issue number1
StatePublished - Jan 25 2013
Externally publishedYes


  • Antiviral and proviral autophagy
  • Selectively autophagy
  • Virophagy

ASJC Scopus subject areas

  • General Medicine


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