Diurnal variations in central venous pressure

B. T. Engel, M. I. Talan

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


We analysed the haemodynamic patterns of seven monkeys (Macaca mulatta) during a one-month period during which we monitored beat-to-beat levels of heart rate, stroke volume, intra-arterial pressure and central venous pressure 7 days/week, 18 h/day. We replicated an earlier finding that cardiac output falls and total peripheral resistance rises throughout the night: the fall in cardiac output was mediated by a fall in heart rate since stroke volume did not change; and the rise in peripheral resistance reflected a homeostatic adjustment to the fall in cardiac output since blood pressure was stable throughout the night although it fell early in the evening. In addition, we have shown for the first time that central venous pressure also falls throughout the night; this occurs even in the presence of α- and β-adrenergic sympathetic blockade. Since stroke volume does not change overnight this indicates that the nocturnal fall in cardiac output is not due to a shift of blood volume into the venous compartment. These findings support our hypothesis that there is a nocturnal decline in plasma volume.

Original languageEnglish (US)
Pages (from-to)273-278
Number of pages6
JournalActa Physiologica Scandinavica
Issue number2
StatePublished - 1991
Externally publishedYes


  • Blood volume
  • Haemodynamics
  • Nocturnal

ASJC Scopus subject areas

  • Physiology


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