Diurnal variation in the therapeutic efficacy of 5-fluorouracil against murine colon cancer

G. J. Peters; J. Van Dijk; J. C. Nadal; C. J. Van Groeningen; J. Lankelma; H. M. Pinedo

Diurnal variation in the therapeutic efficacy of 5-fluorouracil against murine colon cancer

G. J. Peters, J. Van Dijk, J. C. Nadal, C. J. Van Groeningen, J. Lankelma, H. M. Pinedo

Research output: Contribution to journal › Article › peer-review

Abstract

Mice bearing the murine colon carconomas Colon 38 or Colon 26 were treated with 5-fluorouracil (5FU) (60 or 100 mg/kg, respectively) weekly for 4 weeks at 08.30 hr or at 18.30 hr. The antitumor effect of treatment at 08.30 hr was significantly better for both types of tumors, but most pronounced for Colon 38. Toxicity was evaluated after administration of 60 mg 5FU/kg. No thrombocytopenia was observed. Leucopenia was observed after treatment at 18.30 hr. It is concluded that the therapeutic efficacy of 5FU against murine colon cancer is higher when 5FU is administered at 08.30 hr.

Original language	English (US)
Pages (from-to)	113-118
Number of pages	6
Journal	In vivo (Athens, Greece)
Volume	1
Issue number	2
State	Published - 1987
Externally published	Yes

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Medicine(all)

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title = "Diurnal variation in the therapeutic efficacy of 5-fluorouracil against murine colon cancer",

abstract = "Mice bearing the murine colon carconomas Colon 38 or Colon 26 were treated with 5-fluorouracil (5FU) (60 or 100 mg/kg, respectively) weekly for 4 weeks at 08.30 hr or at 18.30 hr. The antitumor effect of treatment at 08.30 hr was significantly better for both types of tumors, but most pronounced for Colon 38. Toxicity was evaluated after administration of 60 mg 5FU/kg. No thrombocytopenia was observed. Leucopenia was observed after treatment at 18.30 hr. It is concluded that the therapeutic efficacy of 5FU against murine colon cancer is higher when 5FU is administered at 08.30 hr.",

author = "Peters, {G. J.} and {Van Dijk}, J. and Nadal, {J. C.} and {Van Groeningen}, {C. J.} and J. Lankelma and Pinedo, {H. M.}",

year = "1987",

language = "English (US)",

volume = "1",

pages = "113--118",

journal = "In Vivo",

issn = "0258-851X",

publisher = "International Institute of Anticancer Research",

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T1 - Diurnal variation in the therapeutic efficacy of 5-fluorouracil against murine colon cancer

AU - Peters, G. J.

AU - Van Dijk, J.

AU - Nadal, J. C.

AU - Van Groeningen, C. J.

AU - Lankelma, J.

AU - Pinedo, H. M.

PY - 1987

Y1 - 1987

N2 - Mice bearing the murine colon carconomas Colon 38 or Colon 26 were treated with 5-fluorouracil (5FU) (60 or 100 mg/kg, respectively) weekly for 4 weeks at 08.30 hr or at 18.30 hr. The antitumor effect of treatment at 08.30 hr was significantly better for both types of tumors, but most pronounced for Colon 38. Toxicity was evaluated after administration of 60 mg 5FU/kg. No thrombocytopenia was observed. Leucopenia was observed after treatment at 18.30 hr. It is concluded that the therapeutic efficacy of 5FU against murine colon cancer is higher when 5FU is administered at 08.30 hr.

AB - Mice bearing the murine colon carconomas Colon 38 or Colon 26 were treated with 5-fluorouracil (5FU) (60 or 100 mg/kg, respectively) weekly for 4 weeks at 08.30 hr or at 18.30 hr. The antitumor effect of treatment at 08.30 hr was significantly better for both types of tumors, but most pronounced for Colon 38. Toxicity was evaluated after administration of 60 mg 5FU/kg. No thrombocytopenia was observed. Leucopenia was observed after treatment at 18.30 hr. It is concluded that the therapeutic efficacy of 5FU against murine colon cancer is higher when 5FU is administered at 08.30 hr.

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JO - In Vivo

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ER -

Diurnal variation in the therapeutic efficacy of 5-fluorouracil against murine colon cancer

Abstract

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