Abstract
The rat model is used to verify disulfiram-associated hypercholesterolemia and to determine a mechanism of action. Administration of disulfiram 15 mg/kg/day for 3 wk is associated with a 25% increase in serum cholesterol which is reversible with discontinuance of the drug. The hypercholesterolemia is due in part to a fourfold increase in activity of hepatic HMG-CoA reductase, the rate-limiting step in cholesterol biosyntheses.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 75-77 |
| Number of pages | 3 |
| Journal | Alcoholism: Clinical and Experimental Research |
| Volume | 5 |
| Issue number | 1 |
| State | Published - 1981 |
| Externally published | Yes |
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Toxicology