Distribution of Capsular Types of Campylobacter jejuni Isolates from Symptomatic and Asymptomatic Children in Peru

Jesús D. Rojas, Nathanael D. Reynolds, Brian L. Pike, Nereyda M. Espinoza, Janelle Kuroiwa, Vihasi Jani, Paul A. Ríos, Rosa G. Nunez, Pablo P. Yori, Manuela Bernal, Rina A. Meza, Margaret N. Kosek, Andrea J. McCoy, Mark P. Simons, Michael J. Gregory, Patricia Guerry, Frédéric M. Poly

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Campylobacter jejuni is the leading bacterial cause of diarrhea worldwide. A capsular polysaccharide (CPS) conjugate vaccine is under development and requires determination of the valency. However, distribution of CPS types circulating globally is presently poorly described. We aimed to determine whether CPS type distribution in Peru differs from that in other endemic regions. We used a multiplex polymerase chain reaction (PCR) assay for the detection of CPS encoding genes capable of distinguishing all 35 CPS types on Campylobacter isolates in two prospective communities based studies conducted in cohorts of children less than 59 months of age in Peru. Results showed that CPS type HS4 complex was the most prevalent, followed by HS3 complex and HS15. Differences in CPS type for symptomatology were not statistically significant. Most subjects demonstrated repeated infections over time with different CPS types, suggesting that CPS types may confer of a level of homologous protective immunity. In this dataset, some differences in CPS type distribution were observed in comparison to other low-middle income countries. Further studies need to be conducted in endemic areas to increase our knowledge of CPS type distribution and guide vaccine development.

Original languageEnglish (US)
Pages (from-to)541-548
Number of pages8
JournalAmerican Journal of Tropical Medicine and Hygiene
Issue number3
StatePublished - 2019

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Virology


Dive into the research topics of 'Distribution of Capsular Types of Campylobacter jejuni Isolates from Symptomatic and Asymptomatic Children in Peru'. Together they form a unique fingerprint.

Cite this