Distortion correction, calibration, and registration: Towards an integrated MR and x-ray interventional suite

Luis F. Gutiérrez, Guy Shechter, Robert J. Lederman, Elliot R. McVeigh, Cengizhan Ozturk

Research output: Chapter in Book/Report/Conference proceedingConference contribution

10 Scopus citations


We present our co-registration results of two complementary imaging modalities, MRI and X-ray angiography (XA), using dual modality fiducial markers. Validation experiments were conducted using a vascular phantom with eight fiducial markers around its periphery. Gradient-distortion-corrected 3D MRI was used to image the phantom and determine the 3D locations of the markers. XA imaging was performed at various C-arm orientations. These images were corrected for geometric distortion, and projection parameters were optimized using a calibration phantom. Closed-form 3D-to-3D rigid-body registration was performed between the MR markers and a 3D reconstruction of the markers from multiple XA images. 3D-to-2D registration was performed using a single XA image by projecting the MR markers onto the XA image and iteratively minimizing the 2D errors between the projected markers and their observed locations in the image. The RMS registration error was 0.77 mm for the 3D-to-3D registration, and 1.53 pixels for the 3D-to-2D registration. We also showed that registration can be performed at a large IS where many markers are visible, then the image can be zoomed in maintaining the registration. This requires calibration of imperfections in the zoom operation of the image intensifier. When we applied the registration used for an IS of 330 mm to an image acquired with an IS of 130 mm, the error was 42.16 pixels before zoom correction and 3.37 pixels after. This method offers the possibility of new therapies where the soft-tissue contrast of MRI and the high-resolution imaging of XA are both needed.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
EditorsR.L. Galloway, Jr., K.R. Cleary
Number of pages11
StatePublished - 2005
EventMedical Imaging 2005 - Visualization, Image-Guided Procedures, and Display - San Diego, CA, United States
Duration: Feb 13 2005Feb 15 2005


OtherMedical Imaging 2005 - Visualization, Image-Guided Procedures, and Display
Country/TerritoryUnited States
CitySan Diego, CA


  • 2D-3D Registration
  • Cardiovascular Intervention
  • Image Registration
  • Image-Guided Surgery
  • MRI
  • X-ray Angiography
  • XMR

ASJC Scopus subject areas

  • Engineering(all)


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