Distinguishing ischemic stroke from the stroke-like lesions of MELAS using apparent diffusion coefficient mapping

Stephen J. Kolb; Fiona Costello; Andrew G. Lee; Matthew White; Stephen Wong; Eric D. Schwartz; Steven R. Messé; Jeffrey Ellenbogen; Scott E. Kasner; Steven L. Galetta

doi:10.1016/S0022-510X(03)00218-1

Distinguishing ischemic stroke from the stroke-like lesions of MELAS using apparent diffusion coefficient mapping

Stephen J. Kolb, Fiona Costello, Andrew G. Lee, Matthew White, Stephen Wong, Eric D. Schwartz, Steven R. Messé, Jeffrey Ellenbogen, Scott E. Kasner, Steven L. Galetta

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

We report two patients with migraine, acute visual field defects and other neurological symptoms who were found to have high T₂ signal and FLAIR abnormalities on brain MRI in temporal and parieto-occipital regions. In these patients, the apparent diffusion coefficient (ADC) of their lesions was increased, distinguishing these lesions from those of ischemic stroke. Both were ultimately diagnosed with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). We conclude that conventional MRI when used with diffusion-weighted MR imaging may be invaluable in detecting mitochondrial-related CNS dysfunction.

Original language	English (US)
Pages (from-to)	11-15
Number of pages	5
Journal	Journal of the Neurological Sciences
Volume	216
Issue number	1
DOIs	https://doi.org/10.1016/S0022-510X(03)00218-1
State	Published - Dec 15 2003
Externally published	Yes

Keywords

Apparent diffusion coefficient
MELAS
Magnetic resonance imaging
Visual loss

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1016/S0022-510X(03)00218-1

Cite this

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title = "Distinguishing ischemic stroke from the stroke-like lesions of MELAS using apparent diffusion coefficient mapping",

abstract = "We report two patients with migraine, acute visual field defects and other neurological symptoms who were found to have high T2 signal and FLAIR abnormalities on brain MRI in temporal and parieto-occipital regions. In these patients, the apparent diffusion coefficient (ADC) of their lesions was increased, distinguishing these lesions from those of ischemic stroke. Both were ultimately diagnosed with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). We conclude that conventional MRI when used with diffusion-weighted MR imaging may be invaluable in detecting mitochondrial-related CNS dysfunction.",

keywords = "Apparent diffusion coefficient, MELAS, Magnetic resonance imaging, Visual loss",

author = "Kolb, {Stephen J.} and Fiona Costello and Lee, {Andrew G.} and Matthew White and Stephen Wong and Schwartz, {Eric D.} and Mess{\'e}, {Steven R.} and Jeffrey Ellenbogen and Kasner, {Scott E.} and Galetta, {Steven L.}",

note = "Funding Information: This work was supported in part by an unrestricted grant from Research to Prevent Blindness, New York, NY. Dr. Kasner was supported by NIH K23 NS02147.",

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doi = "10.1016/S0022-510X(03)00218-1",

language = "English (US)",

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journal = "Journal of the Neurological Sciences",

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T1 - Distinguishing ischemic stroke from the stroke-like lesions of MELAS using apparent diffusion coefficient mapping

AU - Kolb, Stephen J.

AU - Costello, Fiona

AU - Lee, Andrew G.

AU - White, Matthew

AU - Wong, Stephen

AU - Schwartz, Eric D.

AU - Messé, Steven R.

AU - Ellenbogen, Jeffrey

AU - Kasner, Scott E.

AU - Galetta, Steven L.

N1 - Funding Information: This work was supported in part by an unrestricted grant from Research to Prevent Blindness, New York, NY. Dr. Kasner was supported by NIH K23 NS02147.

PY - 2003/12/15

Y1 - 2003/12/15

N2 - We report two patients with migraine, acute visual field defects and other neurological symptoms who were found to have high T2 signal and FLAIR abnormalities on brain MRI in temporal and parieto-occipital regions. In these patients, the apparent diffusion coefficient (ADC) of their lesions was increased, distinguishing these lesions from those of ischemic stroke. Both were ultimately diagnosed with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). We conclude that conventional MRI when used with diffusion-weighted MR imaging may be invaluable in detecting mitochondrial-related CNS dysfunction.

AB - We report two patients with migraine, acute visual field defects and other neurological symptoms who were found to have high T2 signal and FLAIR abnormalities on brain MRI in temporal and parieto-occipital regions. In these patients, the apparent diffusion coefficient (ADC) of their lesions was increased, distinguishing these lesions from those of ischemic stroke. Both were ultimately diagnosed with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). We conclude that conventional MRI when used with diffusion-weighted MR imaging may be invaluable in detecting mitochondrial-related CNS dysfunction.

KW - Apparent diffusion coefficient

KW - MELAS

KW - Magnetic resonance imaging

KW - Visual loss

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Distinguishing ischemic stroke from the stroke-like lesions of MELAS using apparent diffusion coefficient mapping

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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