Distinctive Expression Pattern of ErbB Family Receptors Signifies an Aggressive Variant of Bladder Cancer

Wassim Kassouf, Peter C. Black, Tomasz Tuziak, Jolanta Bondaruk, Sangkyou Lee, Gordon A. Brown, Liana Adam, Caimiao Wei, Keith Baggerly, Menashe Bar-Eli, David McConkey, Bogdan Czerniak, Colin P. Dinney

Research output: Contribution to journalArticlepeer-review

83 Scopus citations


Purpose: Expression of various members of the ErbB family (epidermal growth factor receptor/ErbB-1, ErbB-2, ErbB-3 and ErbB-4) is associated with disease stage and survival in patients with urothelial carcinoma. We examined the correlation of ErbB family receptor expression with the progression of urothelial carcinoma and survival. Materials and Methods: A urothelial carcinoma tissue array was constructed from 248 archival paraffin blocks and quality control studies were ascertained. The tissue microarray was stained for epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4, and analyzed using an automated reader. Patient data included grade, stage, growth pattern, recurrence and survival. Results: Kaplan-Meier estimates of 5-year overall and recurrence-free survival were 58% and 27%, respectively. Patients with high grade, invasive or nonpapillary disease had a worse prognosis than patients with low grade, superficial or papillary disease (p <0.0001). High epidermal growth factor receptor or low ErbB-4 expression was associated with nonpapillary, high grade and invasive tumors as well as with significantly shorter recurrence-free and overall survival (p <0.002, 0.028 and 0.047, respectively). Levels of ErbB-2 and ErbB-3 expression were not associated with overall or recurrence-free survival. Conclusions: The expression profiles of ErbB-4 and epidermal growth factor receptor are prognostic in urothelial carcinoma. They may help in selecting patients at high risk with bladder cancer for more aggressive therapy.

Original languageEnglish (US)
Pages (from-to)353-358
Number of pages6
JournalJournal of Urology
Issue number1
StatePublished - Jan 2008
Externally publishedYes


  • bladder
  • carcinoma
  • microarray analysis
  • protein-tyrosine kinases
  • urothelium

ASJC Scopus subject areas

  • Urology


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