Distinctive clinicopathologic features of the common myxoid soft-tissue lesions

Myxoid change is a nonspecific finding in soft tissue tumours and can be encountered in sarcomas, benign soft tissue neoplasms, and even reactive lesions. For this reason, tumours that are intrinsically myxoid often present a diagnostic dilemma, especially if limited material is available for study. Here we provide a detailed description of four commonly encountered myxoid neoplasms: myxoma, myxoid liposarcoma, myxofibrosarcoma, and low grade fibromyxoid sarcoma. The accompanying differential diagnosis for each will aid the pathologist in the correct classification of myxoid soft tissue tumours.