Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum

Stuart P. Weisberg; Thomas J. Connors; Yun Zhu; Matthew R. Baldwin; Wen Hsuan Lin; Sandeep Wontakal; Peter A. Szabo; Steven B. Wells; Pranay Dogra; Joshua Gray; Emma Idzikowski; Debora Stelitano; Francesca T. Bovier; Julia Davis-Porada; Rei Matsumoto; Maya Meimei Li Poon; Michael Chait; Cyrille Mathieu; Branka Horvat; Didier Decimo; Krystalyn E. Hudson; Flavia Dei Zotti; Zachary C. Bitan; Francesca La Carpia; Stephen A. Ferrara; Emily Mace; Joshua Milner; Anne Moscona; Eldad Hod; Matteo Porotto; Donna L. Farber

doi:10.1038/s41590-020-00826-9

Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum

Stuart P. Weisberg, Thomas J. Connors, Yun Zhu, Matthew R. Baldwin, Wen Hsuan Lin, Sandeep Wontakal, Peter A. Szabo, Steven B. Wells, Pranay Dogra, Joshua Gray, Emma Idzikowski, Debora Stelitano, Francesca T. Bovier, Julia Davis-Porada, Rei Matsumoto, Maya Meimei Li Poon, Michael Chait, Cyrille Mathieu, Branka Horvat, Didier DecimoKrystalyn E. Hudson, Flavia Dei Zotti, Zachary C. Bitan, Francesca La Carpia, Stephen A. Ferrara, Emily Mace, Joshua Milner, Anne Moscona, Eldad Hod, Matteo Porotto, Donna L. Farber

Research output: Contribution to journal › Article › peer-review

Abstract

Clinical manifestations of COVID-19 caused by the new coronavirus SARS-CoV-2 are associated with age^1,2. Adults develop respiratory symptoms, which can progress to acute respiratory distress syndrome (ARDS) in the most severe form, while children are largely spared from respiratory illness but can develop a life-threatening multisystem inflammatory syndrome (MIS-C)^3–5. Here, we show distinct antibody responses in children and adults after SARS-CoV-2 infection. Adult COVID-19 cohorts had anti-spike (S) IgG, IgM and IgA antibodies, as well as anti-nucleocapsid (N) IgG antibody, while children with and without MIS-C had reduced breadth of anti-SARS-CoV-2-specific antibodies, predominantly generating IgG antibodies specific for the S protein but not the N protein. Moreover, children with and without MIS-C had reduced neutralizing activity as compared to both adult COVID-19 cohorts, indicating a reduced protective serological response. These results suggest a distinct infection course and immune response in children independent of whether they develop MIS-C, with implications for developing age-targeted strategies for testing and protecting the population.

Original language	English (US)
Pages (from-to)	25-31
Number of pages	7
Journal	Nature Immunology
Volume	22
Issue number	1
DOIs	https://doi.org/10.1038/s41590-020-00826-9
State	Published - Jan 2021
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1038/s41590-020-00826-9

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Weisberg, S. P., Connors, T. J., Zhu, Y., Baldwin, M. R., Lin, W. H., Wontakal, S., Szabo, P. A., Wells, S. B., Dogra, P., Gray, J., Idzikowski, E., Stelitano, D., Bovier, F. T., Davis-Porada, J., Matsumoto, R., Poon, M. M. L., Chait, M., Mathieu, C., Horvat, B., ... Farber, D. L. (2021). Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum. Nature Immunology, 22(1), 25-31. https://doi.org/10.1038/s41590-020-00826-9

Weisberg, SP, Connors, TJ, Zhu, Y, Baldwin, MR, Lin, WH, Wontakal, S, Szabo, PA, Wells, SB, Dogra, P, Gray, J, Idzikowski, E, Stelitano, D, Bovier, FT, Davis-Porada, J, Matsumoto, R, Poon, MML, Chait, M, Mathieu, C, Horvat, B, Decimo, D, Hudson, KE, Zotti, FD, Bitan, ZC, La Carpia, F, Ferrara, SA, Mace, E, Milner, J, Moscona, A, Hod, E, Porotto, M & Farber, DL 2021, 'Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum', Nature Immunology, vol. 22, no. 1, pp. 25-31. https://doi.org/10.1038/s41590-020-00826-9

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title = "Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum",

abstract = "Clinical manifestations of COVID-19 caused by the new coronavirus SARS-CoV-2 are associated with age1,2. Adults develop respiratory symptoms, which can progress to acute respiratory distress syndrome (ARDS) in the most severe form, while children are largely spared from respiratory illness but can develop a life-threatening multisystem inflammatory syndrome (MIS-C)3–5. Here, we show distinct antibody responses in children and adults after SARS-CoV-2 infection. Adult COVID-19 cohorts had anti-spike (S) IgG, IgM and IgA antibodies, as well as anti-nucleocapsid (N) IgG antibody, while children with and without MIS-C had reduced breadth of anti-SARS-CoV-2-specific antibodies, predominantly generating IgG antibodies specific for the S protein but not the N protein. Moreover, children with and without MIS-C had reduced neutralizing activity as compared to both adult COVID-19 cohorts, indicating a reduced protective serological response. These results suggest a distinct infection course and immune response in children independent of whether they develop MIS-C, with implications for developing age-targeted strategies for testing and protecting the population.",

author = "Weisberg, {Stuart P.} and Connors, {Thomas J.} and Yun Zhu and Baldwin, {Matthew R.} and Lin, {Wen Hsuan} and Sandeep Wontakal and Szabo, {Peter A.} and Wells, {Steven B.} and Pranay Dogra and Joshua Gray and Emma Idzikowski and Debora Stelitano and Bovier, {Francesca T.} and Julia Davis-Porada and Rei Matsumoto and Poon, {Maya Meimei Li} and Michael Chait and Cyrille Mathieu and Branka Horvat and Didier Decimo and Hudson, {Krystalyn E.} and Zotti, {Flavia Dei} and Bitan, {Zachary C.} and {La Carpia}, Francesca and Ferrara, {Stephen A.} and Emily Mace and Joshua Milner and Anne Moscona and Eldad Hod and Matteo Porotto and Farber, {Donna L.}",

note = "Publisher Copyright: {\textcopyright} 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.",

year = "2021",

month = jan,

doi = "10.1038/s41590-020-00826-9",

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AU - Baldwin, Matthew R.

AU - Lin, Wen Hsuan

AU - Wontakal, Sandeep

AU - Szabo, Peter A.

AU - Wells, Steven B.

AU - Dogra, Pranay

AU - Gray, Joshua

AU - Idzikowski, Emma

AU - Stelitano, Debora

AU - Bovier, Francesca T.

AU - Davis-Porada, Julia

AU - Matsumoto, Rei

AU - Poon, Maya Meimei Li

AU - Chait, Michael

AU - Mathieu, Cyrille

AU - Horvat, Branka

AU - Decimo, Didier

AU - Hudson, Krystalyn E.

AU - Zotti, Flavia Dei

AU - Bitan, Zachary C.

AU - La Carpia, Francesca

AU - Ferrara, Stephen A.

AU - Mace, Emily

AU - Milner, Joshua

AU - Moscona, Anne

AU - Hod, Eldad

AU - Porotto, Matteo

AU - Farber, Donna L.

PY - 2021/1

Y1 - 2021/1

N2 - Clinical manifestations of COVID-19 caused by the new coronavirus SARS-CoV-2 are associated with age1,2. Adults develop respiratory symptoms, which can progress to acute respiratory distress syndrome (ARDS) in the most severe form, while children are largely spared from respiratory illness but can develop a life-threatening multisystem inflammatory syndrome (MIS-C)3–5. Here, we show distinct antibody responses in children and adults after SARS-CoV-2 infection. Adult COVID-19 cohorts had anti-spike (S) IgG, IgM and IgA antibodies, as well as anti-nucleocapsid (N) IgG antibody, while children with and without MIS-C had reduced breadth of anti-SARS-CoV-2-specific antibodies, predominantly generating IgG antibodies specific for the S protein but not the N protein. Moreover, children with and without MIS-C had reduced neutralizing activity as compared to both adult COVID-19 cohorts, indicating a reduced protective serological response. These results suggest a distinct infection course and immune response in children independent of whether they develop MIS-C, with implications for developing age-targeted strategies for testing and protecting the population.

AB - Clinical manifestations of COVID-19 caused by the new coronavirus SARS-CoV-2 are associated with age1,2. Adults develop respiratory symptoms, which can progress to acute respiratory distress syndrome (ARDS) in the most severe form, while children are largely spared from respiratory illness but can develop a life-threatening multisystem inflammatory syndrome (MIS-C)3–5. Here, we show distinct antibody responses in children and adults after SARS-CoV-2 infection. Adult COVID-19 cohorts had anti-spike (S) IgG, IgM and IgA antibodies, as well as anti-nucleocapsid (N) IgG antibody, while children with and without MIS-C had reduced breadth of anti-SARS-CoV-2-specific antibodies, predominantly generating IgG antibodies specific for the S protein but not the N protein. Moreover, children with and without MIS-C had reduced neutralizing activity as compared to both adult COVID-19 cohorts, indicating a reduced protective serological response. These results suggest a distinct infection course and immune response in children independent of whether they develop MIS-C, with implications for developing age-targeted strategies for testing and protecting the population.

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Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum

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