Abstract
The parathyroid glands play a crucial role in maintaining nor mal calcium homeostasis, primarily through their regulated secretion of parathyroid hormone. A variety of congenital and acquired causes of diminished parathyroid function exist, including developmental abnormalities and defective parathyroid hormone synthesis or release, and the genetic basis for many of these is known. Primary disorders of parathyroid hyperfunction, mostly owing to parathyroid gland tumors, can be familial or sporadic. Molecular pathogenetic insights into these disorders are substantial, and have been exploited for clinical management.
Original language | English (US) |
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Title of host publication | Principles of Molecular Medicine |
Publisher | Humana Press |
Pages | 357-364 |
Number of pages | 8 |
ISBN (Print) | 9781588292025 |
DOIs | |
State | Published - 2006 |
Externally published | Yes |
Keywords
- Calcium receptor
- cyclin D1
- GCMB
- HRPT2
- hyperparathyroidism
- hypoparathyroidism
- MEN1
- parathyroid
- parathyroid adenoma
- parathyroid carcinoma
- PTH
ASJC Scopus subject areas
- General Medicine