Discovery of keratin function and role in genetic diseases: The year that 1991 was

Pierre A. Coulombe

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

In 1991, a set of transgenic mouse studies took the felds of cell biology and dermatology by storm in providing the frst credible evidence that keratin intermediate flaments play a unique and essential role in the structural and mechanical support in keratinocytes of the epidermis. Moreover, these studies intimated that mutations altering the primary structure and function of keratin flaments underlie genetic diseases typifed by cellular fragility. This Retrospective on how these studies came to be is offered as a means to highlight the 25th anniversary of these discoveries.

Original languageEnglish (US)
Pages (from-to)2807-2810
Number of pages4
JournalMolecular biology of the cell
Volume27
Issue number18
DOIs
StatePublished - Sep 15 2016

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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