Abstract
In 1991, a set of transgenic mouse studies took the felds of cell biology and dermatology by storm in providing the frst credible evidence that keratin intermediate flaments play a unique and essential role in the structural and mechanical support in keratinocytes of the epidermis. Moreover, these studies intimated that mutations altering the primary structure and function of keratin flaments underlie genetic diseases typifed by cellular fragility. This Retrospective on how these studies came to be is offered as a means to highlight the 25th anniversary of these discoveries.
Original language | English (US) |
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Pages (from-to) | 2807-2810 |
Number of pages | 4 |
Journal | Molecular biology of the cell |
Volume | 27 |
Issue number | 18 |
DOIs | |
State | Published - Sep 15 2016 |
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology