Directed inflammation: The phylogeny of lymphokines

R. A. Prendergast, G. A. Lutty, A. L. Scott

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Implants of slow-release polymer Elvax-40 containing purified sea star factor (SSF) and rabbit T cell lymphokines were sutured to the coelomic wall of the distal arms of the sea star Asterias forbesi. Scanning electron microscopic evaluation of the pellet surface demonstrated adherence and spreading of coelomocytes over SSF- or lymphokine-containing pellets examined from 6 to 48 hours after implantation. These observations indicate that purified SSF and rabbit lymphokines demonstrate cross-phylum biological mimicry, implying a phylogenetic link between vertebrate and invertebrate cell communication mechanisms in immunoprotective functions.

Original languageEnglish (US)
Pages (from-to)629-632
Number of pages4
JournalDevelopmental and Comparative Immunology
Issue number4
StatePublished - 1983

ASJC Scopus subject areas

  • Immunology
  • Developmental Biology


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