Abstract
Optimal lymphocyte activation generally requires two concurrent signals, one involving the T cell receptor, and another supplied by an accessory cytokine such as interleukin-1. We investigated the conditions under which partial cellular activation occurs in the absence of signal to the T cell receptor. Both murine thymocytes and the T cell clone D10.G4.1 responded to recombinant interleukin-1 in the absence of a mitogenic signal, although the magnitude of these responses was smaller and required higher concentrations of interleukin-1 than if a comitogen had been present. Interleukin-1 and interleukin-6 in combination were synergistic and induced tritiated thymidine incorporation in D10.G4.1 cells equal to 15% of that obtained with optimal concentrations of concanavalin A. Such synergy suggests that a significant degree of nonspecific activation of lymphocytes may occur in the presence of combinations of monocyte-derived cytokines.
Original language | English (US) |
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Pages (from-to) | 234-240 |
Number of pages | 7 |
Journal | The Journal of Laboratory and Clinical Medicine |
Volume | 117 |
Issue number | 3 |
State | Published - 1991 |
Externally published | Yes |
ASJC Scopus subject areas
- Medicine(all)
- Pathology and Forensic Medicine