Direct effect of angiotensin II on in-vitro perfused rabbit ovary

T. C. Kuo; K. Endo; A. M. Dharmarajan; T. Miyazaki; S. J. Atlas; E. E. Wallach

doi:10.1530/jrf.0.0920469

Direct effect of angiotensin II on in-vitro perfused rabbit ovary

T. C. Kuo, K. Endo, A. M. Dharmarajan, T. Miyazaki, S. J. Atlas, E. E. Wallach

School of Medicine

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

The effects of angiotensin II (AII) and its receptor blocker, saralasin (SAR), on ovulation and oocyte maturation were investigated in an isolated, in-vitro perfused rabbit ovary. Ovulation and oocyte maturation were induced by AII in the absence of human chorionic gonadotrophin (hCG). SAR inhibited ovulation induced by AII or hCG, but not oocyte maturation. AII appears to play a critical role in follicle rupture, but not in resumption of oocyte meiosis.

Original language	English (US)
Pages (from-to)	469-474
Number of pages	6
Journal	Journal of Reproduction and Fertility
Volume	92
Issue number	2
DOIs	https://doi.org/10.1530/jrf.0.0920469
State	Published - 1991

Keywords

Angiotensin II
Oocyte maturation
Ovary
Ovulation
Rabbit
Saralasin

ASJC Scopus subject areas

Physiology
Embryology
Molecular Biology
Obstetrics and Gynecology
Developmental Biology

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10.1530/jrf.0.0920469

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abstract = "The effects of angiotensin II (AII) and its receptor blocker, saralasin (SAR), on ovulation and oocyte maturation were investigated in an isolated, in-vitro perfused rabbit ovary. Ovulation and oocyte maturation were induced by AII in the absence of human chorionic gonadotrophin (hCG). SAR inhibited ovulation induced by AII or hCG, but not oocyte maturation. AII appears to play a critical role in follicle rupture, but not in resumption of oocyte meiosis.",

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AU - Kuo, T. C.

AU - Endo, K.

AU - Dharmarajan, A. M.

AU - Miyazaki, T.

AU - Atlas, S. J.

AU - Wallach, E. E.

PY - 1991

Y1 - 1991

N2 - The effects of angiotensin II (AII) and its receptor blocker, saralasin (SAR), on ovulation and oocyte maturation were investigated in an isolated, in-vitro perfused rabbit ovary. Ovulation and oocyte maturation were induced by AII in the absence of human chorionic gonadotrophin (hCG). SAR inhibited ovulation induced by AII or hCG, but not oocyte maturation. AII appears to play a critical role in follicle rupture, but not in resumption of oocyte meiosis.

AB - The effects of angiotensin II (AII) and its receptor blocker, saralasin (SAR), on ovulation and oocyte maturation were investigated in an isolated, in-vitro perfused rabbit ovary. Ovulation and oocyte maturation were induced by AII in the absence of human chorionic gonadotrophin (hCG). SAR inhibited ovulation induced by AII or hCG, but not oocyte maturation. AII appears to play a critical role in follicle rupture, but not in resumption of oocyte meiosis.

KW - Angiotensin II

KW - Oocyte maturation

KW - Ovary

KW - Ovulation

KW - Rabbit

KW - Saralasin

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Direct effect of angiotensin II on in-vitro perfused rabbit ovary

Abstract

Keywords

ASJC Scopus subject areas

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