Abstract
The effects of angiotensin II (AII) and its receptor blocker, saralasin (SAR), on ovulation and oocyte maturation were investigated in an isolated, in-vitro perfused rabbit ovary. Ovulation and oocyte maturation were induced by AII in the absence of human chorionic gonadotrophin (hCG). SAR inhibited ovulation induced by AII or hCG, but not oocyte maturation. AII appears to play a critical role in follicle rupture, but not in resumption of oocyte meiosis.
Original language | English (US) |
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Pages (from-to) | 469-474 |
Number of pages | 6 |
Journal | Journal of Reproduction and Fertility |
Volume | 92 |
Issue number | 2 |
DOIs | |
State | Published - 1991 |
Keywords
- Angiotensin II
- Oocyte maturation
- Ovary
- Ovulation
- Rabbit
- Saralasin
ASJC Scopus subject areas
- Physiology
- Embryology
- Molecular Biology
- Obstetrics and Gynecology
- Developmental Biology