Direct effect of angiotensin II on in-vitro perfused rabbit ovary

T. C. Kuo, K. Endo, A. M. Dharmarajan, T. Miyazaki, S. J. Atlas, E. E. Wallach

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


The effects of angiotensin II (AII) and its receptor blocker, saralasin (SAR), on ovulation and oocyte maturation were investigated in an isolated, in-vitro perfused rabbit ovary. Ovulation and oocyte maturation were induced by AII in the absence of human chorionic gonadotrophin (hCG). SAR inhibited ovulation induced by AII or hCG, but not oocyte maturation. AII appears to play a critical role in follicle rupture, but not in resumption of oocyte meiosis.

Original languageEnglish (US)
Pages (from-to)469-474
Number of pages6
JournalJournal of Reproduction and Fertility
Issue number2
StatePublished - 1991


  • Angiotensin II
  • Oocyte maturation
  • Ovary
  • Ovulation
  • Rabbit
  • Saralasin

ASJC Scopus subject areas

  • Physiology
  • Embryology
  • Molecular Biology
  • Obstetrics and Gynecology
  • Developmental Biology


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