Dipyridamole potentiates the inhibition by 3'-azido-3'-deoxythymidine and other dideoxynucleosides of human immunodeficiency virus replication in monocyte-macrophages

J. Szebeni; S. M. Wahl; M. Popovic; L. M. Wahl; S. Gartner; R. L. Fine; U. Skaleric; R. M. Friedmann; J. N. Weinstein

Dipyridamole potentiates the inhibition by 3'-azido-3'-deoxythymidine and other dideoxynucleosides of human immunodeficiency virus replication in monocyte-macrophages

J. Szebeni, S. M. Wahl, M. Popovic, L. M. Wahl, S. Gartner, R. L. Fine, U. Skaleric, R. M. Friedmann, J. N. Weinstein

Research output: Contribution to journal › Article › peer-review

Abstract

Dipyridamole (DPM) is commonly used as a coronary vasodilator and inhibitor of platelet aggregation in the treatment of cardiovascular diseases. We report here that DPM potentiates the inhibitory effects of 3'-azido-3'-deoxythymidine (AZT) and 2',3'-deoxycytidine against human immunodeficiency virus type 1 (HIV-1) in human monocyte-macrophages. At the same concentrations, DPM does not potentiate the toxic effects of AZT on these cells or on human bone marrow (granulocyte-monocyte) progenitor cells. Since monocyte-macrophage lineage cells appear to be the major reservoir for HIV-1 in vivo, these findings suggest the possibility of using DPM or its analogues in combination chemotherapy of HIV infections.

Original language	English (US)
Pages (from-to)	3842-3846
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	86
Issue number	10
State	Published - 1989
Externally published	Yes

ASJC Scopus subject areas

General
Genetics

Cite this

Szebeni, J., Wahl, S. M., Popovic, M., Wahl, L. M., Gartner, S., Fine, R. L., Skaleric, U., Friedmann, R. M., & Weinstein, J. N. (1989). Dipyridamole potentiates the inhibition by 3'-azido-3'-deoxythymidine and other dideoxynucleosides of human immunodeficiency virus replication in monocyte-macrophages. Proceedings of the National Academy of Sciences of the United States of America, 86(10), 3842-3846.

Dipyridamole potentiates the inhibition by 3'-azido-3'-deoxythymidine and other dideoxynucleosides of human immunodeficiency virus replication in monocyte-macrophages. / Szebeni, J.; Wahl, S. M.; Popovic, M. et al.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 86, No. 10, 1989, p. 3842-3846.

Research output: Contribution to journal › Article › peer-review

Szebeni, J, Wahl, SM, Popovic, M, Wahl, LM, Gartner, S, Fine, RL, Skaleric, U, Friedmann, RM & Weinstein, JN 1989, 'Dipyridamole potentiates the inhibition by 3'-azido-3'-deoxythymidine and other dideoxynucleosides of human immunodeficiency virus replication in monocyte-macrophages', Proceedings of the National Academy of Sciences of the United States of America, vol. 86, no. 10, pp. 3842-3846.

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title = "Dipyridamole potentiates the inhibition by 3'-azido-3'-deoxythymidine and other dideoxynucleosides of human immunodeficiency virus replication in monocyte-macrophages",

abstract = "Dipyridamole (DPM) is commonly used as a coronary vasodilator and inhibitor of platelet aggregation in the treatment of cardiovascular diseases. We report here that DPM potentiates the inhibitory effects of 3'-azido-3'-deoxythymidine (AZT) and 2',3'-deoxycytidine against human immunodeficiency virus type 1 (HIV-1) in human monocyte-macrophages. At the same concentrations, DPM does not potentiate the toxic effects of AZT on these cells or on human bone marrow (granulocyte-monocyte) progenitor cells. Since monocyte-macrophage lineage cells appear to be the major reservoir for HIV-1 in vivo, these findings suggest the possibility of using DPM or its analogues in combination chemotherapy of HIV infections.",

author = "J. Szebeni and Wahl, {S. M.} and M. Popovic and Wahl, {L. M.} and S. Gartner and Fine, {R. L.} and U. Skaleric and Friedmann, {R. M.} and Weinstein, {J. N.}",

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AU - Szebeni, J.

AU - Wahl, S. M.

AU - Popovic, M.

AU - Wahl, L. M.

AU - Gartner, S.

AU - Fine, R. L.

AU - Skaleric, U.

AU - Friedmann, R. M.

AU - Weinstein, J. N.

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N2 - Dipyridamole (DPM) is commonly used as a coronary vasodilator and inhibitor of platelet aggregation in the treatment of cardiovascular diseases. We report here that DPM potentiates the inhibitory effects of 3'-azido-3'-deoxythymidine (AZT) and 2',3'-deoxycytidine against human immunodeficiency virus type 1 (HIV-1) in human monocyte-macrophages. At the same concentrations, DPM does not potentiate the toxic effects of AZT on these cells or on human bone marrow (granulocyte-monocyte) progenitor cells. Since monocyte-macrophage lineage cells appear to be the major reservoir for HIV-1 in vivo, these findings suggest the possibility of using DPM or its analogues in combination chemotherapy of HIV infections.

AB - Dipyridamole (DPM) is commonly used as a coronary vasodilator and inhibitor of platelet aggregation in the treatment of cardiovascular diseases. We report here that DPM potentiates the inhibitory effects of 3'-azido-3'-deoxythymidine (AZT) and 2',3'-deoxycytidine against human immunodeficiency virus type 1 (HIV-1) in human monocyte-macrophages. At the same concentrations, DPM does not potentiate the toxic effects of AZT on these cells or on human bone marrow (granulocyte-monocyte) progenitor cells. Since monocyte-macrophage lineage cells appear to be the major reservoir for HIV-1 in vivo, these findings suggest the possibility of using DPM or its analogues in combination chemotherapy of HIV infections.

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Dipyridamole potentiates the inhibition by 3'-azido-3'-deoxythymidine and other dideoxynucleosides of human immunodeficiency virus replication in monocyte-macrophages

Abstract

ASJC Scopus subject areas

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